Hormones and Nocturia: Guidelines for Medical Treatment?
An-Sofie Goessaert*, Johan Vande Walle, Ayush Kapila and Karel Everaert
Ghent University Hospital, De Pintelaan 185, 9000 Ghent, Belgium
- *Corresponding Author:
- An-Sofie Goessaert
Urology Department, Ghent University Hospital
De Pintelaan 185, 9000 Ghent, Belgium
Tel: +32 9 332 3603
E-Mail: [email protected]
Received date: March 13, 2014; Accepted date: April 22, 2014; Published date: April 29, 2014
Citation: Goessaert A, Walle JV, Kapila A, Everaert K (2014) Hormones and Nocturia: Guidelines for Medical Treatment?. J Steroids Hormon Sci 5:130. doi:10.4172/2157-7536.1000130
Copyright: © 2014 Goessaert AS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Nocturnal polyuria (NP) is an important cause of nocturia and it is related to an imbalance in water and/or sodium homeostasis. Antidiuretic hormone (ADH) and atrial natriuretic peptide (ANP) are believed to play an important role in this excessive urine production overnight, however, many other hormones are involved. ADH and ANP are both directly and indirectly influenced by the renin-angiotensin-aldosterone system (RAAS), prostaglandins antagonize both ADH and RAAS and sex hormones have a predominantly antidiuretic effect by stimulating ADH and RAAS, meaning that any disturbance can lead to an imbalance in diuresis. Since nocturia is a condition affecting sleep, melatonin secretion can also be affected, leading to a decrease in the antidiuretic effect and to an increase of nocturnal urine production. Depending on the underlying condition affecting any of these hormones, a more specific therapeutic approach might lead to a restoration of the normal diuresis cycle and to a good night’s sleep. The characteristics of each of these hormones, the pathophysiology in NP and the therapeutic implications are set out in this review.