HPV Typization in Vaccinated Women with Cervical LesionsJitka Kobikova1,3*, Jan Evangelista Jirasek2, Marcela Drazdakova4, Miloslav Janousek1, Marie Strunova1, Vaclav Hejda2
and Jaroslav Horacek5
- *Corresponding Author:
- Jitka Kobilkova
Gynecology and Obstetrics University Professor
DrSc, Fellow of International Academy of Cytology
1st Faculty of Medicine, Charles University, Prague, Czech Republic
Tel: 420 266 081 111
E-mail: [email protected]
Received Date: January 20, 2014; Accepted Date: February 24, 2014; Published Date: February 26, 2014
Citation: Kobikova J, Jirasek JE, Drazdakova M, Janousek M, Strunova M, et al. (2014) HPV Typization in Vaccinated Women with Cervical Lesions. J Cytol Histol 5:223. doi:10.4172/2157-7099.1000223
Copyright: © 2014 Kobikova J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background and objective: 24 patients, all of them vaccinated in postpubertal period, on their own descision, all of them had abnormal PAP tests. In all of them an expert colposcopy was performed, in all of them a low and high grade cervical lesion was detected. HPV genotypization, punch biopsy of the lesion folowed by histology and immunohistochemical staining of p16 INK4a were performed.
Study design: Our study concerns 24 patients suffering of cervical lessions. The age of these patients was 20- 34 years. 20 of them were vaccinated by Silgard and 4 of them by Cervarix.
Results: Two patients were hrHPV negative, in 21 patients the cervical lesions were infected with different HPV combinations, only in one woman single hrHPV type 52 was present. The frequent hrHPV types occurence was: 52/11x/, 39/11x/, 31/9x/, 45/6x/, 51/6x/.
Conclusions: Different high risk HPV combinations were present in 21 of 24 examined patients. The p16INK 4a positivity was detected in all lesions in all women examined.