alexa HRT with Cardiovascular and Breast Cancer Risk Reduction
ISSN: 2329-9126

Journal of General Practice
Open Access

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Research Article

HRT with Cardiovascular and Breast Cancer Risk Reduction

Khalid Mahmud*
Medical Director, Innovative Directions in Health, USA
Corresponding Author : Khalid Mahmud, MD
FACP, Medical Director
Innovative Directions in Health
7550 France Avenue S., Suite 215
Edina, MN 55435 USA
Tel: 952-922-2345
Fax: 952-922-1309
E-mail: [email protected]
Received August 13, 2013; Accepted November 01, 2013; Published November 07, 2013
Citation: Mahmud K (2013) HRT with Cardiovascular and Breast Cancer Risk Reduction. J Gen Pract 1:131. doi:10.4172/2329-9126.1000131
Copyright: © 2013 Mahmud K. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The Women’s Health Initiative [WHI] study ended in 2002 because of the adverse effects of Premarin and Provera, including cardiovascular events [heart attack, stroke and pulmonary embolism] which affected 7% of the participants, and almost doubling the risk of breast cancer and mammographic abnormalities. It led to a major reduction in the use of hormone therapy for menopausal women, with significant consequences in terms of quality of life and possibly overall health. The following is a report of 460 menopausal women, who were administered multiple hormones, according to a rationalized approach described below. All patients received bio-identical estrogen and progesterone; 227 and 349 received testosterone and DHEA, respectively for suboptimal levels; 103 received thyroid replacement, and 89 received a growth hormone secretagogue for suboptimal Insulin like Growth factor [IGF]. No patient developed any cardiovascular complications over an average duration of four years. Premarin and Provera would have resulted in 33 such events. There were no hormone related breast cancers and no increase in mammographic abnormalities. In fact, eight abnormal [dense/cystic] mammograms showed improvement on follow up. There is a need to look into fresh approaches that could improve the quality and possibly quantity of menopausal years.

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