HSV-1 Enters Melanocytes and Induces their ApoptosisJing Lan, Yuxiao Hong, Ruiqun Qi, Song Zheng and Xing-Hua Gao*
Department of Dermatology, No. 1 Hospital of China Medical University, 155 North Nanjing Street, Shenyang 110001, China
- *Corresponding Author:
- Xing-Hua Gao
Department of Dermatology
No. 1 Hospital of China Medical University
155 North Nanjing Street, Shenyang 110001, China
E-mail: [email protected]
Received Date: September 02, 2016; Accepted Date: October 20, 2016; Published Date: October 31, 2016
Citation: Lan J, Hong Y, Qi R, Zheng S, Gao XH (2016) HSV-1 Enters Melanocytes and Induces their Apoptosis. Pigmentary Disorders 3: 246. doi:10.4172/2376-0427.1000246
Copyright: © 2016 Lan J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Herpes simplex virus type 1 (HSV-1) enters into the host and makes a disease. HSV-1 can infect many types of cells but epidermis is a target in which keratinocytes are the main attacked cells. Melanocytes are important components of the epidermis and have a close relationship with keratinocytes. Many studies are on “the effects of HSV-1 on keratinocytes”; less is known about the effects of HSV-1 on melanocytes. In this study, we treated murine Melan-A cell line with HSV-1 in vitro and draw a conclusion that HSV-1 can infect melanocytes and induce melanocytes apoptosis for the first time.