alexa Human bocavirus (HBov1 and HBov2) in Children with Acut
ISSN: 2472-1212

Journal of Antimicrobial Agents
Open Access

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Research Article

Human bocavirus (HBov1 and HBov2) in Children with Acute Gastroenteritis from North India

Kapoor R and Dhole TN*

Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India

*Corresponding Author:
Dr. Tapan N Dhole (MD)
Professor and Head Department of Microbiology
Sanjay Gandhi Post Graduate Institute of Medical Sciences
Lucknow, Uttar Pradesh, India
Tel: +91-522-2494263
E-mail: [email protected]

Received date: July 21, 2016; Accepted date: August 23, 2016; Published date: August 30, 2016

Citation: Kapoor R, Dhole TN (2016) Human bocavirus (HBov1 and HBov2) in Children with Acute Gastroenteritis from North India. J Antimicro 2:124. doi:10.4172/2472-1212.1000124

Copyright: © 2016 Kapoor R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objective: Human bocavirus is responsible for respiratory as well as in gastroenteritis illness in several countries including India. This study was aimed to characterize the Human bocavirus in North Indian children suffering with acute gastroenteritis.

Methods: A total of 234 diarrheal stool specimens from the children under the age of 15 years were collected and screened for the presence of Human bocavirus by polymerase chain reaction targeting NS1 and VP1/2 gene followed by sequencing and phylogenetic analysis. Student’s t test was performed for statistical analysis of quantitative clinical data.

Results: Total 7 (3%) samples were positive for Human bocavirus including bocavirus1 (n=4, 1.7%) and bocavirus2 (n=3, 1.3%). Median age of bocavirus positive children was 8 months (mean ± SD; 24.14 ± 27.58 months). Age, duration of diarrhea and episodes of diarrhea were the significant clinical factors (p values 0.0486, 0.0015 and 0.0282 respectively) for bocavirus infection. Interestingly, male were dominated than females (6:1). Phylogenetic analysis showed that Indian bocavirus sequence has similarity with China strains.

Conclusion: Detection of two bocavirus species in gastroenteritis from North India supports global presence of bocavirus. The outcome of the study facilitates more detailed studies of bocavirus infection, its prevalence and disease association in Indian population.

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