alexa Human CD4+ Memory T-cell Populations Secrete Th1 Cytokines in Response to Influenza Antigen Stimulation | OMICS International | Abstract
ISSN: 2157-7560

Journal of Vaccines & Vaccination
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Human CD4+ Memory T-cell Populations Secrete Th1 Cytokines in Response to Influenza Antigen Stimulation

Shan Chen1, David Roumanes2, Maria T. Arevalo1, Yanping Chen1 and Mingtao Zeng1,2*

1The Center of Excellence for Infectious Diseases, Department of Biomedical Sciences, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas, USA

2The Department of Microbiology & Immunology, School of Medicine and Dentistry, University of Rochester, Rochester, New York, USA

These two authors are equal contributors

*Corresponding Author:
Dr. Mingtao Zeng
Ph.D./Associate Professor
Center of Excellence for Infectious Diseases
Department of Biomedical Sciences
Paul L. Foster School of Medicine
Texas Tech University Health Sciences Center
5001 El Paso Drive, El Paso, Texas 79905, USA
Tel: +1 915 7831241 ext 253
Fax: +1 915 7831271
E-mail: [email protected]

Received Date: March 14, 2012; Accepted Date: March 23, 2012; Published Date: March 25, 2012

Citation: Chen S, Roumanes D, Arevalo MT, Chen Y, Zeng M (2012) Human CD4+ Memory T-cell Populations Secrete Th1 Cytokines in Response to Influenza Antigen Stimulation. J Vaccines Vaccin 3:129. doi: 10.4172/2157-7560.1000129

Copyright: © 2012 Chen S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Seasonal influenza vaccine efficacy is measured by the vaccine’s ability to elicit strain-specific antibody responses. Every year, resources are allocated into formulating new influenza vaccines. Candidate vaccines utilizing memory T-cells may afford long-term protection. Our study characterizes the human CD4+ memory T-cell response to influenza virus. Intracellular cytokine staining assay was used to assess T-cell production of several cytokines (IFN-γ, IL-2, TNF-α, IL-4, IL-5, and IL-17) found in human peripheral blood mononuclear cells after stimulation with influenza antigens. Production of Th1 cytokines (IFN-γ, TNF-α, and IL-2) was significant in activated CD4+ T-cells after stimulation, whereas Th2 cytokine secretion remained unchanged. In addition, a significant increase in multifunctional CD4+ T-cells that simultaneously secreted combinations of IL-2, IFN-γ, and TNF-α was observed. Our studies have revealed that CD4+ T-cell responses against influenza are Th1-biased, raising the possibility of identifying these populations as targets for successful influenza vaccination

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