alexa Human Leukocyte Antigens and Host Factors are Associated with Good Health in Ageing Indian Population
ISSN: 2161-1041

Hereditary Genetics: Current Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Human Leukocyte Antigens and Host Factors are Associated with Good Health in Ageing Indian Population

Mahendra N Mishra1* and Puja Dudeja2

1Dr Lal Path Labs Pvt. Ltd, National Reference Laboratory, New Delhi, India

2Post Graduate Institute of Medical Research, Chandigarh, India

*Corresponding Author:
Mahendra N Mishra
Dr Lal Path Labs Pvt. Ltd, National Reference Laboratory
Block–E, Sector 18, Rohini, New Delhi-110085, India
Tel/Fax: 911130244178
E-mail: [email protected]

Received date February 18, 2014; Accepted date: May 21, 2014; Published date: May 23, 2014

Citation: Mishra MN, Dudeja P (2014) Human Leukocyte Antigens and Host Factors are Associated with Good Health in Ageing Indian Population. Hereditary Genet 3:128. doi: 10.4172/2161-1041.1000128

Copyright: © 2014 Mishra MN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background: An efficient functional immune system is likely to be responsible for both good health and longevity. The human leukocyte antigen (HLA) system is responsible for many aspects of immunity.
Aims and objectives: This case-control study was carried out with to study the association of HLA with longevity and good health in Asian Indian population. The results of tissue-typing by serology and role of host factors in longevity was also evaluated.
Methods: A detailed questionnaire was administered to all 76 participants and 75 controls which included family history of longevity followed by a thorough clinical examination, routine hematological and biochemical testing. Tissue-typing in cases was performed by microlymphocytotoxicity (n=70), sequence specific primers (SSP) (n =06) or both (n=39) for class I antigens and by SSP for class II antigens. Statistical analysis was carried out by Chisquare test. P values and Odds ratio were calculated.
Results: A higher frequency of A*30, C*06, DRB1*13, DPB1*04:01 and *04:02 was present in the subjects
whereas A*29, A*33, B*07, B*35, B*44, C*01, C*07, C*15 DRB1*04 was seen in the controls of which the antigens
B*15, C*07 and C*15 were statistically significant. Longevity was found to be clustered in families. The study also
brought out the polymorphism for DPB1 alleles min Asian Indians.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords