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Case Report

Human Mesenchymal Stem Cell Transfusion for End Stage Liver Disease: A Case Series and Literature Review

Wen-Bo Meng1,2,3,4, Bing Bai1,2,3,4, Ying Li2,3,4, Jian-jun Zhang2,3,4, Yong-long Guo2,3,4, Wen-Ce Zhou2,3,4, Yan Li5* and Xun Li2,3,4*

1Special Minimally Invasive Surgery, 1st hospital of Lanzhou university, Lanzhou, China

2The Second General Surgery Department, 1st hospital of Lanzhou University, Lanzhou, China

3Hepatopancreatobiliary Surgery Institute of Gansu Province, Clinical Medical College Cancer Center of Lanzhou University, Lanzhou, China

4Key Laboratory of Biological Therapy and Regenerative Medicine Transformation, Gansu, China

5Department of Immunology, Cleveland Clinic, Cleveland, OH, USA

Corresponding Authors :
Yan Li
Department of Immunology
Cleveland Clinic, Cleveland, OH, USA
Tel: 001216-444-2200
E-mail: [email protected]
Xun Li
The Second General Surgery Department
1st Hospital of Lanzhou University, Lanzhou, China
Tel: 0931-8625200
E-mail: [email protected]

Received: October 30, 2015; Accepted: December 16, 2015; Published: December 24, 2015

Citation: Meng WB, Bai B, Li Y, Zhang JJ, Guo YL, et al. (2015) Human Mesenchymal Stem Cell Transfusion for End Stage Liver Disease: A Case Series and Literature Review. J Immunooncol 1:101. doi:10.4172/joi.1000101

Copyright: © 2015 Meng W, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Decompensated liver cirrhosis is a severe, life-threatening situation in end-stage liver disease. Liver transplantation is the only effective therapy regarding on this. Unfortunately the shortage of liver donors, vast of patients died during enrolled in the waiting list. There are increasing reports of using stem cell to treat advanced liver disease nowadays worldwide, and if it could be alternative therapy in persons with end-stage liver disease is not so clear. Herein we describe a case series outcome of Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSCs) transfusions for decompensated liver cirrhosis and also reviewed the literature on stem cell therapy.


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