alexa Human Mesenchymal Stem Cells Migrate toward Colon Cancer Partially Regulated by HMGB1 | OMICS International | Abstract
ISSN: 2157-7013

Journal of Cell Science & Therapy
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Research Article

Human Mesenchymal Stem Cells Migrate toward Colon Cancer Partially Regulated by HMGB1

Go Hoshino1, Hiroshi Yagi1*, Hirotoshi Hasegawa1, Yoshiyuki Ishii1, Koji Okabayashi1, Hiroto Kikuchi1, Akimasa Yasuda2, Yo Mabuchi5, Masaya Nakamura2, Yumi Matsuzaki4, Hideyuki Okano3 and Yuko Kitagawa1
1Department of Surgery, School of Medicine, Keio University, Japan
2Department of Orthopedics, School of Medicine, Keio University, Japan
3Department of Physiology, School of Medicine, Keio University, Japan
4Institute of Medical Science, Tokyo Medical University, Japan
5Department of Biochemistry and Biophysics, Graduate School of Health Care, Tokyo Medical and Dental University, Japan
Corresponding Author : Hiroshi Yagi
Department of Surgery, School of Medicine
Keio University, 35 Shinanomach
Shinjuku-ku, Tokyo, 160-8582, Japan
Tel: +81-3-3355-1211 (ext:62334)
Fax: +81-3-3355-4707
E-mail: [email protected]
Received June 13, 2013; Accepted September 20, 2013; Published September 23, 2013
Citation: Hoshino G, Yagi H, Hasegawa H, Ishii Y, Okabayashi K, et al. (2013) Human Mesenchymal Stem Cells Migrate toward Colon Cancer Partially Regulated by HMGB1. J Cell Sci Ther 4:145. doi: 10.4172/2157-7013.1000145
Copyright: © 2013 Hoshino G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Although Mesenchymal Stem Cells (MSC) have been explored as a new clinically relevant cell type to repair injured tissue, a number of studies have highlighted the important aspect of MSC therapy. Studies have shown that systemically administered MSCs migrate to sites of malignant tumor. The focus of this study was to identify the mechanism of migration of human MSCs into cancerous tissue. First, the effect of cultured medium from cancer cell lines on modulating the migration of MSCs was evaluated, using seven different human colon cancer cell lines. Interestingly, the secretion level of High Mobility Group Box 1 (HMGB1) protein from each cell line affected the migration capacity of MSCs. In addition, recombinant human HMGB1 increased MSC’s migration capacity in a dose-dependent manner. Finally, 1×106 human MSCs were injected subcutaneously into mice (n=14) with colon cancer tumors that secreted high levels of HMGB1. Bioluminescence live image analysis showed that MSCs surrounded the tumors after injection into these mice through day 6. Immunohistochemical analysis using CD90 as a specific antibody revealed the existence of MSCs in and around the tumors as well as the secretion of local HMGB1 from the tumors detected by anti-HMGB1 antibody. These findings are critical in understanding the role of MSCs in development of solid tumors and further, they offer insight that may be useful in therapeutic application of MSCs in the treatment of malignant tumors.

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