alexa Human Papilloma Virus (HPV) Vaccines: Scope and Implica
ISSN: 2161-1025

Translational Medicine
Open Access

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Review Article

Human Papilloma Virus (HPV) Vaccines: Scope and Implications

Roshan Kumar Singh1, Sandeep Satapathy2* and Abhilasha Singh1

1Department of Zoology, University of Delhi, Delhi, India

2Department of Biological Sciences, Institute of Science Education and Research, Bhopal, India

*Corresponding Author:
Sandeep Satapathy
Department of Biological Sciences
Institute of Science Education and Research
Bhopal, India
Tel: 09437543777
Email: [email protected]

Received date: June 08, 2016; Accepted date: June 23, 2016; Published date: July 12, 2016

Citation: Sandeep S, Roshan KS, Abhilasha S (2016) Human Papilloma Virus (HPV) Vaccines: Scope and Implications. Transl Med (Sunnyvale) 6:180. doi:10.4172/2161-1025.1000180

Copyright: © 2016 Sandeep S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

High risk human papilloma virus has often been associated with cancer onset and progression by the virtue of the viral oncogenes. Genital cancers and Oropharyngeal cancers are the two leading carcinomas often induced by HPV infection. These viral encoded oncogenes (e.g. E6/E7/E8) are known for their ability to integrate, recombine and interfere with the host cellular genes. Although significant work has been undertaken and several more in progress in understanding the disease biology, yet attaining an effective and long term protection from HPV associated cancers remains unachieved. Lack of any drug based therapy or post-infection treatment strategy along with limited commercially available vaccines (e.g. Gardasil and Cervarix) have crippled our efforts to curb the disease manifestation cancers, remains. Therefore, in this review we aim to address the contemporary rational of HPV vaccine designing and development. We have also analyzed the scope and future perspectives of the commercially available vaccine regimes.

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