alexa Human Salivary Acidic Proline-Rich Proteins (APRP-1/2) In Adult Patients With Dental Caries
ISSN: 2161-1122

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Research Article

Human Salivary Acidic Proline-Rich Proteins (APRP-1/2) In Adult Patients With Dental Caries

Anna K Szkaradkiewicz-Karpińska1, Marta Sak2, Olga Goślińska-Kuźniarek2, Jerzy Sokalski3 and Andrzej Szkaradkiewicz2*

1Department of Conservative Dentistry and Periodontology, University of Medical Sciences in Poznan, Poland

2Department of Medical Microbiology, University of Medical Sciences in Poznan, Poland

3Department of Dental Surgery, University of Medical Sciences in Poznan, Poland

*Corresponding Author:
Andrzej Szkaradkiewicz
Department of Medical Microbiology, University of Medical Sciences in Poznan
Wieniawskiego 3 Street, Poznan, Poland
Tel.: +48 61 8546 138
Fax: +48 61 8546 140
E-mail: [email protected]

Recieved Date: May 10, 2017; Accepted Date: May 23, 2017; Published Date: May 26, 2017

Citation: Szkaradkiewicz-Karpinska AK, Sak M, Goslinska-Kuzniarek O, Sokalski J, Szkaradkiewicz J (2017) Human Salivary Acidic Proline-Rich Proteins (APRP-1/2) In Adult Patients With Dental Caries. Dentistry 7:437. doi: 10.4172/2161-1122.1000437

Copyright: © 2017 Szkaradkiewicz-Karpińska AK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Acidic proline-rich proteins (APRPs) are manifested in human saliva in various phenotypes and represent its important component. The unique structure of their two isoforms. APRP-1/2 as well as their coupling to hydroxyapatite and formation of the acquired enamel pellicle are well known. Nevertheless, role of APRP-1/2 in adult patients with dental caries still remains unclear. The aim of this study was to analyze the levels of APRP-1/2 in saliva of adult patients with dental caries. Patients and Methods: The studies were conducted on 106 adult patients which were qualified to individual groups on grounds of dental examination and calculation of DMFT index. Group 1 (control) included 18 caries-free patients (DMFT=0). Group 2 included 20 persons (DMFT=2.3 ± 1.0) with very low intensity of caries. Group 3 included 20 patients (DMFT=6.2 ± 1.3) with low intensity of caries. Group 4 comprised 24 patients (DMFT=10.9 ± 1.8) with moderate intensity of caries. Group 5 included 24 patients (DMFT=19.5 ± 3.5) with high intensity of dental caries. Concentrations of APRP-1/2 in saliva were estimated using PRH2 ELISA kit (MyBioSource). Results: In persons of group 1 (control) concentration of APRP-1/2 averaged at 15.2 ± 2.6 ng/ml. This concentration did not statistically differ from results obtained in patients of groups 2. On the other hand in patients of groups 3, 4 and 5 mean values of APRP-1/2 concentrations amounted respectively to: 18.6 ± 3.2 ng/ml, 35.4 ± 4.6 ng/ml and 39.8 ± 5.1 ng/ml. The obtained values of APRP-1/2 were significantly higher than results obtained in group 1 (p<0.05; Mann-Whitney test). In parallel the numerical force of women and men examined in the distinguished groups manifested no significant differences (p>0.05; test for two independent proportions). Conclusions: High levels of APRP-1/2 in saliva of adult patients may be involved in intensification of the caries process.


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