alexa Humulus Scandens Chemical Constituents Determination an
ISSN: 2161-0444

Medicinal Chemistry
Open Access

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Research Article

Humulus Scandens Chemical Constituents Determination and Pharmacological Action Research

Zaixing Chen1*, Shu Meng2, Jiao Yang3, Hongguang Nie1, Hong Jiang4, Huiyuan Hu1 and Fanhao Meng1

1School of Pharmaceutical Sciences, China Medical University, 92 Beier Road, Shenyang, Liaoning Province 110001, People’s Republic of China

2Liaoning Institute of Family Planning, 10 Puhe Street, Shenyang, Liaoning Province 110031, People’s Republic of China

3Department of Pharmacy, The General Hospital of Daqing Oilfield, Daqing 163001, China

4School of Public Health, China Medical University, 92 Beier Road, Shenyang, Liaoning Province 110001, People’s Republic of China

*Corresponding Author:
Zaixingchen
School of Pharmaceutical Sciences
China Medical University, 92 Beier Road
Shenyang, Liaoning Province 110001
People’s Republic of China
Tel: 86-02481119987
E-mail: [email protected]

Received date: March 01, 2012; Accepted date: March 14, 2012; Published date: March 15, 2012

Citation: Chen Z, Meng S, Yang J, Nie H, Jiang H, et al. (2012) Humulus Scandens Chemical Constituents Determination and Pharmacological Action Research. Med chem 2:029-032. doi:10.4172/2161-0444.1000109

Copyright: © 2012 Chen Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Humulus Scandens has been widely used for a long time in folk medicine, but it has not been systematically researched until now. The aims of this study were to isolate the components and simultaneously determine the contents of luteolin-7-O-β-D-glucoside (LGL) and apigenin-7-O-β-D-glucoside (AGL) in the different parts of H. Scandens. At the same time, our research team verified the anti-cancer activity and the alveolar fluid clearance (AFC) of H. Scandens total flavonoids (HSTF), LGL and AGL. The anti-cancer experiment showed that HSTH and LGL have a significant inhibition effect on the HepG2 cell. The cell viability decreased when drug concentration increased, but AGL has an indistinctive effect on HepG2 cell under the same concentration. The AFC experiment showed that AFCs of HSTF, LGL and AGL, compared to the blank control group, increased, which explained the H. Scandens pharmacological effect of removing edema. This result provides the theoretical basis for H. Scandens clinical application.

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