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Hunting the Risk NPY and ACE Polymorphisms as Predictors of Cardiovascular Diseases: Case Report and Review of the Literature | OMICS International | Abstract
ISSN: 2165-8048

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Case Report

Hunting the Risk NPY and ACE Polymorphisms as Predictors of Cardiovascular Diseases: Case Report and Review of the Literature

Vincenza Rita Lo Vasco1*, Rita Businaro2, Francesco Massoni3, Giovanni Borghini4, Mariangela Corsi2, Claudio Simeone3 and Serafino Ricci3
1Department of Sense Organs, Sapienza University of Rome, P.le A. Moro, 5 - 00185 Rome, Italy
2Science and Biotechnologies Medical-Surgery, Sapienza University of Rome, P.le A. Moro, 5 - 00185 Rome, Italy
3Department of Anatomical, Histological, Medical Legal and Locomotive System Sciences, Sapienza University of Rome, P.le A. Moro, 5 - 00185 Rome, Italy
4Department of Infectious Diseases, Microbiology and Public Health Sciences, Sapienza University of Rome, P.le A. Moro, 5 - 00185 Rome, Italy
*Corresponding Author : Vincenza Rita Lo Vasco
Sense Organs Department
Sapienza University of Rome, Italy
Tel: 0649976814
E-mail: [email protected]
Received November 08, 2013; Accepted January 17, 2014; Published January 25, 2014
Citation: Vasco VRL, Businaro R, Massoni F, Borghini G, Corsi M, et al. (2014) Hunting the Risk NPY and ACE Polymorphisms as Predictors of Cardiovascular Diseases: Case Report and Review of the Literature. Intern Med S11:004. doi:10.4172/2165-8048.S11-004
Copyright: © 2013 2014 Vasco VRL. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Many research efforts were addressed to identify individuals at high risk for multifactorial diseases, such as cardiovascular alterations and related diseases. Great interest was paid to investigate the genetic liability in multifactorial illnesses. The prognosis of high-risk patients might be greatly ameliorated using genetic predisposition risk factors, such as the polymorphisms of neuropeptide Y (NPY) and Angiotensin converting enzyme (ACE) genes. Epidemiologic results suggest that selected polymorphisms of both NPY and ACE might be helpful to improve the evaluation of patients, offering a powerful prognostic tool and paving the way to novel molecular therapeutic strategies.
We present a case report of a male, sudden-death from myocardial infarction, presenting with left ventricular hypertrophy. The patient carried polymorphisms of ACE and NPY genes, respectively ACE genotype ID and NPY genotype T-399C, actually considered as risk factors.

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