alexa Hyaluronan-Binding T Regulatory Cells in Peripheral Blood of Breast Cancer Patients
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Research Article

Hyaluronan-Binding T Regulatory Cells in Peripheral Blood of Breast Cancer Patients

Yuliya Perfilyeva1, Yekaterina Ostapchuk1, Esin Aktas Cetin2, Abdullah Yilmaz2, Gunnur Deniz2, Shynar Talaeva3, Nazgul Omarbaeva3, Igor Oskolchenko1and Nikolai Belyaev1*
1Laboratory of Molecular Immunology and Immunobiotechnology, M.A.Aitkhozhin’s Institute of Molecular Biology and Biochemistry, 050012 Almaty, Kazakhstan
2Department of Immunology, Institute of Experimental Medicine (DETAE), Istanbul University, 34393 Istanbul, Turkey
3Mammology Center, Research Institute of Radiology and Oncology, 480072 Almaty, Kazakhstan
Corresponding Author : Nikolai Belyaev
Doctor of Biological Sciences
Professor, M.A. Aitkhozhin’s
Institute of Molecular Biology and Biochemistry
Laboratory of Molecular Immunology and Immunobiotechnology
86 Dosmukhamedov St., 050012, Almaty, Kazakhstan
Tel: +7-705-874-08-50
Fax: +7-727-293-70-92
E-mail: [email protected]
Received December 03, 2014; Accepted January 15, 2015; Published January 22, 2015
Citation: Perfilyeva Y, Ostapchuk Y, Cetin EA, Yilmaz A, Deniz G, et al. (2015) Hyaluronan-Binding T Regulatory Cells in Peripheral Blood of Breast Cancer Patients. J Clin Cell Immunol 6:286. doi: 10.4172/2155-9899.1000286
Copyright: © 2015 Perfilyeva Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Regulatory T cells (Treg), both natural and induced, play an important role in maintaining immune homeostasis. Alterations in the number and functions of Tregs are involved in tumor growth. One of the possible regulatory mechanisms of Treg functional activity involves interaction with major component of extracellular matrix hyaluronan. It has been demonstrated that high molecular weight hyaluronan promotes Treg function via increased expression of FoxP3 and production of IL-10. Moreover, previous research has shown highly enhanced suppressor function of hyaluronan-binding CD4+CD25+ Tregs in mice. Breast cancer is characterized by upregulated production of tumorassociated hyaluronan, therefore we investigated hyaluronan-binding subset of Tregs obtained from peripheral blood of breast cancer patients. As a result, we showed that the majority of peripheral blood Tregs were able to adhere to immobilized hyaluronan, and these cells exerted superior suppressor activity, suggesting a key role in regulatory functions of these cells. The percentage of CD4+FoxP3+ Treg cells binding hyaluronan, as well as CD39+ hyaluronan-binding Tregs were significantly increased in breast cancer patients compared to healthy donors. Enhanced number of the activated Treg cells might play an important role in the suppression of antitumor immunity.

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