alexa Hyperechogenicity of Lenticular Nuclei in Primary Cervical Dystonia | OMICS International| Abstract
ISSN: 2329-6895

Journal of Neurological Disorders
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  • Research Article   
  • J Neurol Disord 2017, Vol 6(2): 380
  • DOI: 10.4172/2329-6895.1000380

Hyperechogenicity of Lenticular Nuclei in Primary Cervical Dystonia

Agnieszka Krzak-Kubica1*, Stanisław Ochudło1, Justyna Gawryluk1, Krzysztof Pawlicki2 and Monika Rudziń Ska-Bar1
1Department of Neurology, Medical University of Silesia, University Medical Center, Katowice, Poland
2Department of Biophysics, Medical University of Silesia, University Medical Center, Katowice, Poland
*Corresponding Author : Agnieszka Krzak-Kubica, Medical University of Silesia, University Medical Center, Katowice, Poland, Tel: +48 32 208 36 00, Email: [email protected]

Received Date: Mar 19, 2018 / Accepted Date: Apr 26, 2018 / Published Date: Apr 30, 2018


Dystonia is one of the most common movement disorders, but the pathogenesis of primary dystonia is not fully understood. One of the proposed pathomechanisms is the deficiency or dysfunction of ATP-dependent Menkes protein responsible for the extracellular transport of copper within subcortical nuclei, the lack of which could lead to increased accumulation of copper in the lenticular nucleus (LN). In 1995, Naumann et al. performed transcranial sonography (TCS) on patients with dystonia for the first time. Other researchers confirmed more frequent occurrence of hyperechogenic LN more than 70% patients with cervical dystonia. The aim of our study was therefore to evaluate the prevalence of hyperechogenic changes in lenticular nucleus of the brain in patients with cervical dystonia. 108 patients were considered eligible for inclusion; 42 of them were subsequently excluded due to occurrence of exclusion criteria. Thus, the study involved 66 patients and 71 controls. Hyperechogenicity of the lenticular nucleus was found more often in patients with cervical dystonia than in controls (p<0.0001). It was unilateral in majority of patients (75.8%). The average surface area of hyperechogenic changes is bigger in dystonic patients compare with control group 0,05 (± 0,10) vs 0,005 (± 0,02) on the left side and 0,10 (± 0,12) vs. 0.004 (± 0.02) on the right side. Hyperechogenicity of lenticular nuclei were observed in the case of 8 patients (11.2%) within the control group and they were unilateral changes. Substantia nigra hyperechogenicity did not differ between the two groups. We did not find a correlation between the size of the observed changes and dystonia severity or duration of the disease. The only correlation was the association between the width of the third ventricle and age of patients. We suggest that the hyperechogenic changes within the lenticular nuclei are prevalent in patient with primary cervical dystonia and are an important diagnostic clue.

Keywords: Transcranial sonography; Lenticular nucleus; Primary cervical dystonia

Citation: Kubica AK, Ochudło S, Gawryluk J, Pawlicki K, Bar MR (2018) Hyperechogenicity of Lenticular Nuclei in Primary Cervical Dystonia. J Neurol Disord 6:380. Doi: 10.4172/2329-6895.1000380

Copyright: © 2018 Kubica AK. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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