Hyperglycemia as a Risk Factor of Ischemic StrokeZiyan Zhang, Jingqi Yan and Honglian Shi*
Department of Pharmacology & Toxicology, University of Kansas, Lawrence, Kansas, USA
- *Corresponding Author:
- Honglian Shi, Ph.D
Associate Professor, Department of Pharmacology and Toxicology
University of Kansas, School of Pharmacy, 1251 Wescoe Hall Drive
Malott Hall 5044, Lawrence, KS 66045, USA
Tel: 1-785-864- 6193
E-mail: [email protected]
Received date: April 01, 2013; Accepted date: June 27, 2013; Published date: June 29, 2013
Citation: Zhang Z, Yan J, Shi H (2013) Hyperglycemia as a Risk Factor of Ischemic Stroke. J Drug Metab Toxicol 4:153. doi: 10.4172/2157-7609.1000153
Copyright: © 2013 Zhang Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Diabetes is considered a major risk factor for stroke and is associated with worsened stroke outcomes. Here, we discuss and summarize the mechanisms that have been associated with the increased risk of stroke due to the hyperglycemia in diabetes mellitus. In diabetic stroke models, hyperglycemia exaggerates the following damaging processes: acidosis, accumulation of reactive oxygen species/reactive nitrogen, inflammation and mitochondrial dysfunction. Understanding the mechanism of diabetes acting as a stroke risk factor will definitely assist to reveal issues related to drug metabolism and toxicity in diabetic stroke. In addition, it is suggested that future studies may focus on the mechanisms mediating blood-brain barrier and astrocytes dysfunction under hyperglycemic stroke.