Hyper-Homocysteinemia: A Potential Indicator of Acute Pancreatitis
- *Corresponding Author:
- Lian-Cai Wang
Department of Hepatobiliary Surgery
Henan Provincial People’s Hospital
Zhengzhou University, China
Tel: +86- 37165897522
E-mail: [email protected]
Received Date: December 17, 2015; Accepted Date: December 22, 2015; Published Date: January 28, 2016
Citation:Zhang LC, Li QY, Zhang JX, Wang LC (2016) Hyper-Homocysteinemia: A Potential Indicator of Acute Pancreatitis. J Bioengineer & Biomedical Sci S3:002. doi:10.4172/2155-9538.S3-002
Copyright: © 2016 Zhang LC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
Objectives: Hyper-homocysteinemia, reportedly, is closely associated with some known vascular dysfunctions, thrombosis and even inflammations. However, till now rare studies were directed to the association between hyperhomocysteinemia and acute pancreatitis (AP). The illumination of this potential association is expected to benefit therapies of AP. In this regard, this study aims at digging the underlying association between hyper-homocysteinemia and AP.
Methods: In this study, 160 patients with AP were involved. The plasma levels of homocysteine of these patients were measured. The patients were divided into two groups, based on the serum homocysteine concentration. Patients with high plasma homocysteine concentrations (C>15 µmol/L) were classified as Group 1, while the rest with normal plasma homocysteine concentrations (5 µmol/L ≤ C ≤ 15 µmol/L) were identified as Group 2. Then, the lipid levels for the two groups were studied to detect whether there existed a synergistic effect of hyper-homocysteinemia and hypertriglyceride on AP.
Results: Almost half (46.9%) of the patients with AP were found to bear hyper-homocysteinemia in this study. However, patients in Group 1 were found to have lower triglyceride and total cholesterol levels than those in Group 2, with P=0.038 and P=0.046 respectively. In addition, more patients in Group 2 had hyper-triglyceride and hyper-total cholesterol than those in Group 1, though the differences were not significantly observed.
Conclusions: In conclusion, these studies showed that hyper-homocysteinemia may be a very important indicator of a high risk of AP. So, more attention should be paid to hyper-homocysteinemia in the progress of AP.