Hypertension in Pregnancy: The Role of Circulating Endothelial Progenitor Cell DysfunctionAlexander E Berezin*
Consultant of Therapeutic Unit, Internal Medicine Department, State Medical University, Mayakovsky av, Zaporozhye, Ukraine
- *Corresponding Author:
- Alexander E Berezin
Consultant of Therapeutic Unit
Internal Medicine Department
State Medical University, 26
Mayakovsky av, Zaporozhye, Ukraine
E-mail: [email protected]; [email protected]
Received Date: March 18, 2017; Accepted Date: March 28, 2017; Published Date: April 05, 2017
Citation: Berezin AE (2017) Hypertension in Pregnancy: The Role of Circulating Endothelial Progenitor Cell Dysfunction. J Hypertens 6:240. doi:10.4172/2167-1095.1000240
Copyright: © 2017 Berezin AE. This is an open-access article distributed under the terms of the Creative Commons Attribution License; which permits unrestricted use; distribution; and reproduction in any medium; provided the original author and source are credited.
Pregnancy-induced hypertension (PIH) development associates well with considerable abnormalities in the structure and function of vascular endothelium. Lowered number and weak function of circulating endothelial progenitor cells (EPCs) as a marker of worsening endothelial integrity were recognized a promising indicator of PIHrelated clinical outcomes. Although there are limiting data regarding predictive usefulness of serial EPC count measurement in pregnant women, it has been postulated that EPC dysfunction could be got better prognostication than other biomarkers including serum inflammatory cytokines, von Willebrand factor, E-selectin in prediction of some severe PIH-related states, i.e., fetoplacental insufficiency and premature parturitions. The sort communication is depicted the role of EPC dysfunction as a promising biomarkers in PIH.