alexa Hypertensive Emergency in Adolescent with Systemic Lupus Erythematosus at Onset: A Case Report

Immunological Disorders & Immunotherapy
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Case Report

Hypertensive Emergency in Adolescent with Systemic Lupus Erythematosus at Onset: A Case Report

Maria Elena Cucuzza1*, Maria Teresa Garozzo1, Daniele Attardo1, Stefania Tomarchio1, Chiara Franzonello1, Giovanni Conti2, Salvatore Leonardi1 and Patrizia Barone1

1Department of Clinical and Experimental Medicine, University of Catania, Italy

2Pediatric of Nephrology and Rheumatology Unit, University of Messina, Italy

*Corresponding Author:
Maria Elena Cucuzza
Department of Clinical and Experimental Medicine
University of Catania, Italy
Tel: +39-95-3781193, +39-95-3782940
Fax: +39-95-3782940
E-mail: [email protected]

Received date: May 25, 2016; Accepted date: June 10, 2016; Published date: June 13, 2016

Citation: Cucuzza ME, Garozzo MT, Attardo D, Tomarchio S, Franzonello C, et al. (2016) Hypertensive Emergency in Adolescent with Systemic Lupus Erythematosus at Onset: A Case Report. Immunol Disord Immunother 2: 105. doi:10.4172/idit.1000105

Copyright: © 2016 Cucuzza ME, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The severity of Systemic lupus erythematosus (SLE) at onset represents the most important biomarker of disease outcome and of treatment response in paediatric patients. Kidney disease, chronic systemic inflammation and steroid toxicity could cause hypertension development. Thirteen year old child presenting with serositis, hemolytic anemia, leucopenia, thrombocytopenia and lupus nephritis was treated according to Euro Lupus Protocol. A progressive deterioration of kidney function was observed during the treatment with increased blood pressure for about a month after the beginning of the treatment. The antihypertensive therapy established by the Italian society of pediatrics (SIP) and consisting of diuretic therapy (Furosemide 1 mg/Kg/die) and angiotensin-converting-enzyme (ACE) inhibitor therapy (Enalapril 0.06 mg/Kg/die) was initiated. Persisting hypertensive peaks, calcium antagonist therapy (Amlodipina 5 mg/die) and α2 adrenergic therapy (Clonidina one plaster/2.5 mg/week) were added. After gaining control of the hypertensive peaks, the antihypertensive treatment was gradually reduced. There are no treatment protocols for the management of hypertension associated with SLE in children in the literature. In our case the early treatment with the SIP protocol determined reduction in urinary protein levels and avoided acute organ damage related to hypertension peaks.


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