alexa Hypertriglyceridemic-Waist Phenotype is a Useful Global Assessment Tool for Predicting Acute Myocardial Infarction
ISSN: 2329-9517

Journal of Cardiovascular Diseases & Diagnosis
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Research Article

Hypertriglyceridemic-Waist Phenotype is a Useful Global Assessment Tool for Predicting Acute Myocardial Infarction

Grace M. Egeland1,2*, Jannicke Igland2, Ottar Nygard3,4, Gerhard Sulo2 and Grethe S. Tell1,2
1Division of Health Registries, Norwegian Institute of Public Health, Bergen, Norway
2Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway
3Department of Clinical Science, University of Bergen, Bergen, Norway
4Department of Heart Disease, Haukeland University Hospital, Bergen, Norway
Corresponding Author : Egeland GM
Department of Global Public Health and Primary Care & Norwegian Institute of Public Health
Kalfarveien 31, N-5018 Bergen, Norway
Tel: +47 53204065
E-mail: [email protected]
Received: June 19, 2015; Accepted: July 06, 2015; Published: July 08, 2015
Citation: Egeland GM, Igland J, Nygard O, Sulo G, Tell GS (2015) Hypertriglyceridemic-Waist Phenotype is a Useful Global Assessment Tool for Predicting Acute Myocardial Infarction. J Cardiovasc Dis Diagn 3:207. doi:10.4172/2329-9517.1000207
Copyright: © 2015 Egeland GM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Background: There has been growing research interest in exploring the utility of the hypertriglyceridemicwaist phenotype as a predictor of cardio-metabolic risk. To date, prospective studies evaluating the phenotype as a predictor of cardiovascular disease have provided variable results. Objectives: To evaluate the usefulness of the hypertriglyceridemic-waist phenotype as an independent predictor of acute myocardial infarction beyond classical cardiovascular disease risk factors in a homogeneous Norwegian population. Methods: Norwegian health survey (Cohort Norway) participants (n=116,111), free of heart disease in 1994- 2003, were followed through 2009 by record linkages to The Cause of Death Registry and hospital discharge diagnoses through the Cardiovascular disease in Norway project. Cox proportional hazards analyses adjusted for conventional risk factors. Results: During a mean follow-up of 11.5 yrs (SD=2.8), 3,624 participants developed an acute myocardial infarction. Prevalence of an enlarged waist (>102 cm for men, and >88 cm for women) increased from the lowest to highest quartile of triglycerides for men (4.9% to 22.5%) and women (6.5% to 42.1%; P for trend < 0.01). The presence of an enlarged waist and elevated triglyceride (>1.7 mmol/L) was associated with a hazard ratio for acute myocardial infarction of 1.68 (95% CI 1.48-1.90) for men and 1.95 (95% CI 1.66-2.29) for women compared to those with normal waist and triglyceride level after adjusting for age, smoking and time since last meal. However, 75% of the excess risk was mediated by HDL and nonHDL cholesterol. Conclusions: The phenotype is a useful global assessment tool but of limited value when conventional risk factors are available. Patients presenting with the phenotype should be targeted with lifestyle interventions and referred for clinical follow-up.

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