alexa Hypertriglyceridemic-Waist Phenotype is a Useful Global
ISSN: 2329-9517

Journal of Cardiovascular Diseases & Diagnosis
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Hypertriglyceridemic-Waist Phenotype is a Useful Global Assessment Tool for Predicting Acute Myocardial Infarction

Grace M. Egeland1,2*, Jannicke Igland2, Ottar Nygard3,4, Gerhard Sulo2 and Grethe S. Tell1,2
1Division of Health Registries, Norwegian Institute of Public Health, Bergen, Norway
2Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway
3Department of Clinical Science, University of Bergen, Bergen, Norway
4Department of Heart Disease, Haukeland University Hospital, Bergen, Norway
Corresponding Author : Egeland GM
Department of Global Public Health and Primary Care & Norwegian Institute of Public Health
Kalfarveien 31, N-5018 Bergen, Norway
Tel: +47 53204065
E-mail: [email protected]
Received: June 19, 2015; Accepted: July 06, 2015; Published: July 08, 2015
Citation: Egeland GM, Igland J, Nygard O, Sulo G, Tell GS (2015) Hypertriglyceridemic-Waist Phenotype is a Useful Global Assessment Tool for Predicting Acute Myocardial Infarction. J Cardiovasc Dis Diagn 3:207. doi:10.4172/2329-9517.1000207
Copyright: © 2015 Egeland GM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at Pubmed, Scholar Google


Background: There has been growing research interest in exploring the utility of the hypertriglyceridemicwaist phenotype as a predictor of cardio-metabolic risk. To date, prospective studies evaluating the phenotype as a predictor of cardiovascular disease have provided variable results. Objectives: To evaluate the usefulness of the hypertriglyceridemic-waist phenotype as an independent predictor of acute myocardial infarction beyond classical cardiovascular disease risk factors in a homogeneous Norwegian population. Methods: Norwegian health survey (Cohort Norway) participants (n=116,111), free of heart disease in 1994- 2003, were followed through 2009 by record linkages to The Cause of Death Registry and hospital discharge diagnoses through the Cardiovascular disease in Norway project. Cox proportional hazards analyses adjusted for conventional risk factors. Results: During a mean follow-up of 11.5 yrs (SD=2.8), 3,624 participants developed an acute myocardial infarction. Prevalence of an enlarged waist (>102 cm for men, and >88 cm for women) increased from the lowest to highest quartile of triglycerides for men (4.9% to 22.5%) and women (6.5% to 42.1%; P for trend < 0.01). The presence of an enlarged waist and elevated triglyceride (>1.7 mmol/L) was associated with a hazard ratio for acute myocardial infarction of 1.68 (95% CI 1.48-1.90) for men and 1.95 (95% CI 1.66-2.29) for women compared to those with normal waist and triglyceride level after adjusting for age, smoking and time since last meal. However, 75% of the excess risk was mediated by HDL and nonHDL cholesterol. Conclusions: The phenotype is a useful global assessment tool but of limited value when conventional risk factors are available. Patients presenting with the phenotype should be targeted with lifestyle interventions and referred for clinical follow-up.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version