alexa Hyperuricemia and Adverse Pregnancy Outcomes in Ghanaian Women: Potential Mechanism | OMICS International
ISSN: 2161-1009

Biochemistry & Analytical Biochemistry
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Research Article

Hyperuricemia and Adverse Pregnancy Outcomes in Ghanaian Women: Potential Mechanism

Ababio GK1*, Adu-Bonsaffoh K2, Botchway F3, Abindau E4 and Quaye IKE5

1Department of Medical Biochemistry, University of Ghana SBAHS, Accra, Ghana

2Department of Obstetrics and Gynecology, Korle-Bu Teaching Hospital, Accra, Ghana

3Department of Child Health, Korle-Bu Teaching Hospital, Accra, Ghana

4Department of Physiology, University of Ghana SBAHS, Accra, Ghana

5Department of Medical Biochemistry, University of Namibia, School of Medicine, Accra, Ghana

*Corresponding Author:
Ababio GK
Department of Medical Biochemistry
University of Ghana SBAHS
Accra, Ghana
Tel: +233-302-666987-8
Fax: +233-302-663062
E-mail: [email protected]

Received date: March 22, 2016; Accepted date: May 21, 2016; Published date: May 24, 2016

Citation: Ababio GK, Adu-Bonsaffoh K, Botchway F, Abindau E, Quaye IKE (2016) Hyperuricemia and Adverse Pregnant Outcomes in Ghanaian Women: Potential Mechanism. Biochem Anal Biochem 5: 275. doi:10.4172/2161-1009.1000275

Copyright: © 2016 Ababio GK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Hyperuricemia has been associated with pre-eclampsia (PE) but limited data exist on the potential mechanism for the association. It is therefore imperative that data is collated for the pathogenic role of urate in PE; hence the focus.

Aim: To investigate the association between uric acid levels and pregnancy outcomes in Ghanaian women.

Methodology: The nested case control study was located at the Obstetrics and Gynecology department of the Korle-Bu Teaching Hospital (KBTH). One hundred and fourteen consented subjects were recruited after ethical clearance was obtained and structured questionnaire administered to them. Four milliliter (4 ml) blood and five milliliter (5 ml) urine samples were taken for biochemical analysis and urinalysis respectively. An automated chemistry analyzer was used to quantify blood chemistry. The data was captured as protected health information (PHI) and analyzed with SPSS version 18.

Results: In pre-eclampsia, patients with hyperuricemia (>360 umol/L) were associated with low birth weight (1033.3 ± 57.7). Among the pregnant women with lesser weeks of gestation (< 34 weeks), PE patients had their uric acid levels elevated, Apgar scores decreased and birth-weight decreased compared to ≥ 34 weeks gestation category.

Conclusion: Increased uric acid levels could generate free radicals that might impair the endothelial system and cause adverse pregnant outcomes.

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