alexa Hypocalcaemia as a Prognostic Factor of Mortality and Morbidity in Moderate and severe Traumatic Brain Injury and its role with Protein S-100b
ISSN: 2329-6895

Journal of Neurological Disorders
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Research Article

Hypocalcaemia as a Prognostic Factor of Mortality and Morbidity in Moderate and severe Traumatic Brain Injury and its role with Protein S-100b

José Luna-Muñoz*

Brain Bank-LaNSE of CINVESTAV-IPN, México, CDMX, México

*Corresponding Author:
José Luna-Muñoz
Brain Bank-LaNSE of CINVESTAVIPN, México, CDMX, México
Tel: +5257473800
Fax: +5257473800
E-mail: [email protected]

Received date: May 10, 2017; Accepted date: June 10, 2017; Published date: June 14, 2017

Citation: Luna-Muñoz J (2017) Hypocalcaemia as a Prognostic Factor of Mortality and Morbidity in Moderate and severe Traumatic Brain Injury and its role with Protein S-100b. J Neurol Disord 5:346. doi:10.4172/2329-6895.1000346

Copyright: © 2017 Luna-Muñoz J. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Introduction: The effects of traumatic brain injury (TBI) can result in severe disability or death and have an important social and economic impact. Its annual direct and indirect costs amount to roughly 2.5 billion euros. Our objective was to evaluate whether hypocalcaemia of serum ionized calcium (defined as <1.10 mmol/L (4.5 mg/dL) is a prognostic factor for mortality and morbidity (defined as GOS ≤ 3) in early moderate and severe TBI.

Material and methods: Prospective study from January 2014 to December 2015. Patients were between 16 and 87 years old and had a Glasgow Coma Scale (GCS) of 3-13 points following TBI, with demonstrable intracranial lesions in cranial computed tomography (CT).

Results: We recruited 61 patients who suffered moderate and severe TBI with a median age of 42 years old (range: 17 to 86). Forty-three (70.50%) male 18 (29.50%) female. Twenty-one (34.42%) patients had a GOS ≤ 3 and 40 (65.58%) a GOS >3. We found a significant statistical difference (0.009) in ionized serum calcium, Protein S-100b (0.002), IL 6 (0.007) and Haemoglobin (0.011) on day three of admission between GOS ≤ 3 and >3 (disability/death). The best logistic regression model included: age, absent pupillary reactivity, hypocalcaemia of ionized serum calcium (<1.10 mmol/L), Protein S100 b and IL6 on day three.

Conclusion: Hypocalcaemia looks like being an epiphenomenon of several factors. It seems to play a role as prognosticator, however not as leverage point for therapy.


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