alexa Hypocomplementemic Urticarial Vasculitis with Crescentic Glomerulonephritis, Interstitial Nephritis and Small Vessel Vasculopathy: Case Report and Mini- Review
ISSN: 2161-0959

Journal of Nephrology & Therapeutics
Open Access

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Case Report

Hypocomplementemic Urticarial Vasculitis with Crescentic Glomerulonephritis, Interstitial Nephritis and Small Vessel Vasculopathy: Case Report and Mini- Review

Zakharova EV1*, Stolyarevich ES2, Vorobjova OL3 and Zvonova EV1

1Department of Nephrology, City Clinical Hospital n.a. S.P. Botkin, Moscow, Russian Federation

2Department of Pathology, City Clinical Hospital #52, Moscow, Russian Federation

3Department of Pathology, National Centre of Clinical Morphology, St-Petersburg, Russian Federation

*Corresponding Author:
Elena Zakharova
Head of Nephrology Unit
City Clinical Hospital n.a. S.P. Botkin
Moscow, Russian Federation
Tel: +7 967 134 6936
E-mail:[email protected]

Received Date: September 21, 2016; Accepted Date: November 01, 2016; Published Date: November 07, 2016

Citation: Zakharova EV, Stolyarevich ES, Vorobjova OL, Zvonova EV (2016) Hypocomplementemic Urticarial Vasculitis with Crescentic Glomerulonephritis, Interstitial Nephritis and Small Vessel Vasculopathy: Case Report and Mini-Review. J Nephrol Ther 6: 263. doi: 10.4172/2161-0959.1000263

Copyright: © 2016 Zakharova E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License; which permits unrestricted use; distribution; and reproduction in any medium; provided the original author and source are credited.



Hypocomplementemic urticarial vasculitis (HUV) is the rare immune complex vasculitis, affecting small vessels and associated with anti-C1q antibodies, presenting with urticaria and hypocomplementemia. Glomerulonephritis, arthritis, obstructive pulmonary disease, and ocular inflammation are common in HUV. HUV may present as an idiopathic disease or be a part of systemic autoimmune or autoinflammatory condition, like systemic lupus erythematosus, arthritis-hives-angioedema (AHA) syndrome, cryoglobulinemic vasculitis, Schnitzler syndrome, Cogan’s syndrome and Muckle–Wells syndrome. Renal involvement includes proteinuria, sometimes of nephrotic range, hematuria and usually moderately impaired kidney function. Various pathology variants were found in patients with HUV: mesagnial proliferative, membranoproliferative, focal proliferative, membranous, minimal change, crescentic and severe sclerosing proliferative glomerulonephritis. Interstitial nephritis and C1q-associated small vessel vasculopathy are poorly described. Here we present a case of HUV with combined renal damage - crescentic glomerulonephritis, interstitial nephritis and small vessel vasculopathy, successfully treated with immunosuppressant’s, and discuss the differential diagnostics of HUV.


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