Hypoglycemic and Hypolipidemic Effects of Raisin Aqueous Extract “Karkni” in Alloxan-Induced Diabetic Rats
- *Corresponding Author:
- Fatma Ghrairi
Laboratory of Biochemistry
Faculty of Medicine Sousse
Mohamed Karoui Avenue
99/UR/08-45, 4002 Sousse, Tunisia
Fax: +216 73224899
E-mail: [email protected]
Received date: July 27, 2012; Accepted date: September 14, 2012; Published date: September 19, 2012
Citation:Ghrairi F, Amira EA, Henda C, Lahouar L, Achour L, et al. (2012) Hypoglycemic and Hypolipidemic Effects of Raisin Aqueous Extract “Karkni” in Alloxan-Induced Diabetic Rats. J Diabetes Metab 3:211. doi:10.4172/2155-6156.1000211
Copyright: © 2012 Ghrairi F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The present study was carried out to investigate the possible antioxidant effects of raisin extract “Karkni” on biochemical parameters in alloxan-induced diabetic rats. Three doses of extract, 125, 250 and 375 mg/kg were orally administered daily to alloxan-diabetic rats for 4 weeks. Alloxan-induced diabetic rats showed significant increases in the levels of blood glucose, triglycerides, cholesterol, low density lipoprotein LDL-cholesterol, creatinine, uric acid, total protein, glycosylated hemoglobin (HbA1c), Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) while high density lipoprotein HDL cholesterol, total hemoglobin and lactate dehydrogenase (LDH) levels were significantly decreased compared to normal rats (P<0.05). The changes of the above parameters to their normal levels after 4 weeks of treatment were observed mainly with the second dose 250 mg/kg. The overall results suggest that the “Karkni” extract possesses potential hypoglycemic and hypolipidemic activity in alloxan-induced diabetic rats.