alexa Hypoglycemic and Hypolipidemic Potential of Nigella sativa L. Seed Extract in Streptozotocin (STZ)-Induced Diabetic Rats | OMICS International
ISSN: 2329-9029

Journal of Plant Biochemistry & Physiology
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Research Article

Hypoglycemic and Hypolipidemic Potential of Nigella sativa L. Seed Extract in Streptozotocin (STZ)-Induced Diabetic Rats

Asaduzzaman M1*, Lutfun Nahar2, Sohanur Rahman M1, Mahadi Hasan3, Anowara Khatun4, Zinat Tamanna1, Nazmul Huda1, Fazley Rabbi M1, Manobendro Nath Ray5, Nur Islam M5, Mobassirul Islam M5, Maniruzzaman M5 and Mehfuz Alam1
1Department of Biochemistry and Molecular Biology, University of Rajshahi, Bangladesh
2Gonoshasthaya Samaj Vittik Medical College and Hospital, Dhaka, Bangladesh
3Department of Biophysical Chemistry, Kyoto Pharmaceutical University, Japan
4Department of Pharmacology, Kyoto Pharmaceutical University, Japan
5Department of Pharmacy, University of Rajshahi, Bangladesh
*Corresponding Author : Md. Asaduzzaman
Department of Biochemistry and Molecular Biology
University of Rajshahi, Rajshahi-6205, Bangladesh
Tel: +8801719248007
E-mail: [email protected]
Received October 20, 2015; Accepted October 16, 2015; Published October 23, 2015
Citation: Asaduzzaman M, Nahar L, Rahman MS, Hasan M, Khatun A, et al. (2015) Hypoglycemic and Hypolipidemic Potential of Nigella sativa L. Seed Extract in Streptozotocin (STZ)-Induced Diabetic Rats. J Plant Biochem Physiol 3:158. doi:10.4172/2329-9029.1000158
Copyright: © 2015 Asaduzzaman M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Diabetes mellitus (DM) is the most common metabolic disease worldwide. Multiple medications and side effects, the most significant and prevalent themes in diabetes mellitus ultimately determine novel directions and avenues in drug discovery. The objective of this study was to determine the effects of NS (Nigella sativa) L. Seed hydroalcholic Extract on hypoglycemic and hypolipidemic condition in Streptozotocin- induced diabetic rats. DM was induced by single intraperitoneal injection of freshly prepared Streptozotocin (STZ) (65 mg/kg body weight) solution. Mice were divided into six groups. This study was conducted for 28 days and blood glucose level was measured at 7 days interval. Hyperlipidemic was induced by mixture of cholesterol (1.5%) and cholic acid (0.5%) with diet of rats. At the end of the treatment, the blood glucose level and lipid profile was measured by using commercial kits. It was observed that NS (Nigella sativa) has a potential hypoglycemic effect as it significantly (p<0.001) decrease blood glucose level compared to diabetic group. The SGPT, SGOT and CRP were also decreased significantly (p<0.05). Therefore NS (Nigella sativa) might be effective against liver malfunction. An indicative antilipidemic effect was also observed as TC, TG, LDL, VLDL showed significant (p<0.05) decrease whereas HDL showed significant increase (p<0.001) by NS (Nigella sativa) treatment compared to diabetic group. These results showed that hydroalcholic extract of NS (Nigella sativa) at low doses has hypoglycemic effect and as well as lipid profile in diabetic subjects. Nigella sativa is a potential protective natural agent against atherosclerosis, hepatoprotective and cardiovascular complication in diabetes rats.

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