Hypolipidemic Effect of Purslane (Portulaca oleracea L.) in Rats Fed on High Cholesterol Diet
Niharika Shanker and Sukumar Debnath*
Department of Traditional Food and Sensory Science, CSIR-Central Food Technological Research Institute, Mysore-570020, India
- *Corresponding Author:
- Sukumar Debnath
Department of Traditional Food and Sensory Science
CSIR-Central Food Technological Research Institute, Mysore-570020, India
E-mail: [email protected]
Received Date: August 22, 2016; Accepted Date: September 22, 2016; Published Date: September 30, 2016
Citation: Shanker N, Debnath S (2016) Hypolipidemic Effect of Purslane (Portulaca oleracea L.) in Rats Fed on High Cholesterol Diet. J Nutr Food Sci 6:557. doi: 10.4172/2155-9600.100557
Copyright: © 2016 Debnath S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Purslane is a vegetarian source of n-3 PUFA (α-linolenic acid). The objective of the present work was to explore purslane as n-3 source to mitigate hyperlipidemia in rat model. Group of rats (n=48) were fed on high cholesterol diet to induce hyperlipidemia. Group 1,2,3,4 and 5 (n=6/group) were fed on aqueous extract of purslane (AEP) and lovastanin diet while group 6 and 7 were treated as hyperlipidemic and normal control. The results revealed a significant (p<0.05) reduction in serum TC, LDL-C, VLDL-C, TAG, increase in serum HDL-C level observed in AEP fed rats as compared to cholesterol induced hyperlipidemic control group. Groups treated with AEP and lovastatin also demonstrated considerable decrease in LDL-C: HDL-C ratios, levels of SGOT, SGPT, ALP activities and body weight in comparison to control group. Therefore, administration of AEP concluded that 150 mg/kg body weight AEP is a potent cardio-protective agent having preventive and curative effect against hyperlipidemia.