alexa Hyponatremia and Voltage Gated Potassium Channel Antibody Associated Limbic Encephalitis | OMICS International | Abstract
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
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Research Article

Hyponatremia and Voltage Gated Potassium Channel Antibody Associated Limbic Encephalitis

Newey CR1* and Sarwal A2

1 Cleveland Clinic 9500 Euclid Avenue Cleveland, OH 44195-5245, USA

2 Neurology and Critical Care, Wake Forest Baptist Medical center, Medical Center Boulevard Winston Salem, USA

Corresponding Author:
Christopher Newey
1160 S Michigan Avenue #3103 Chicago
IL 60605, USA
Tel: 216-444-2200
E-mail: cr[email protected]

Received date: January 19, 2014; Accepted date: February 19, 2014; Published date: March 01, 2014

Citation: Newey CR, Sarwal A (2014) Hyponatremia and Voltage Gated Potassium Channel Antibody Associated Limbic Encephalitis. J Neurol Neurophysiol 5:195. doi:10.4172/2155-9562.1000195

Copyright: © 2014 Newey CR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Limbic encephalitis may occur as an infectious, paraneoplastic, or autoimmune phenomenon. One such cause
of limbic encephalitis is voltage gated potassium channel antibodies (VKGC). Hyponatremia with new cognitive
decline may be one of the presenting symptoms. The exact mechanism of hyponatremia is unknown though findings
consistent with syndrome of inappropriate antidiuretic hormone (SIADH) are observed. We retrospectively reviewed
all cases admitted to an academic medical center with a diagnosis of limbic encephalitis (848 adults between 2004
to 2010) and found six cases of VGKC antibody associated limbic encephalitis. Three of the six cases had SIADH
that completely or partially resolved with a combination of water restriction and immunotherapy. The reversibility of
hyponatremia and limbic encephalitis with immunomodulation suggests an antibody-mediated cause. We further
review available literature for association of hyponatremia and VGKC limbic encephalitis and propose mechanisms of
for the hyponatremia in autoimmune encephalitis


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