alexa Hypophosphatemic Osteomalacia Associated with Tenofovir Use in HIVInfected Patients: A Case Series and Review of the Literature
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

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Case Report

Hypophosphatemic Osteomalacia Associated with Tenofovir Use in HIVInfected Patients: A Case Series and Review of the Literature

Angelique Tjen-A-Looi1*, Shabnam N Naseer1, Angus B Worthing2, Joseph G Timpone3* and Princy N Kumar4

1Clinical Infectious Diseases Fellow, Division of Infectious Diseases, Georgetown University Hospital, Washington DC, USA

2Arthritis and Rheumatism Associates, PC, Washington, DC/Chevy Chase, MD, Georgetown University Hospital, Washington DC, USA

3Associate Professor, Division of Infectious Diseases, Associate Program Director, Internal Medicine Residency Program, Georgetown University Hospital, Washington DC, USA

4Chief and Fellowship Director, Division of Infectious Diseases, Professor of Medicine and Microbiology, Department of Medicine, Vice Chair for Education, Associate Dean for Students, School of Medicine, Georgetown University Hospital, Washington DC, US

*Corresponding Author:
Angelique Tjen-A-Looi
Clinical Infectious Diseases Fellow
Division of Infectious Diseases
Georgetown University Hospital
Washington DC, USA
Tel: 916-973-5230
E-mail: [email protected]

Joseph G Timpone
Associate Professor, Division of Infectious Diseases
Associate Program Director, Internal Medicine Residency Program
Georgetown University Hospital, Washington DC, USA
Tel: 202-444-0135
Fax: 1-877-665-8072
E-mail: [email protected]

Received Date: October 13, 2012; Accepted Date: October 26, 2012; Published Date: October 29, 2012

Citation: Tjen-A-Looi A, Naseer SN, Worthing AB, Timpone JG, Kumar PN (2012) Hypophosphatemic Osteomalacia Associated with Tenofovir Use in HIV-Infected Patients: A Case Series and Review of the Literature. J AIDS Clinic Res S4:008. doi:10.4172/2155-6113.S4-008

Copyright: © 2012 Tjen-A-Looi A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

We present three cases of HIV-infected patients who developed Fanconi syndrome, hypophosphatemic osteomalacia and bone fractures while on tenofovir, a nucleotide reverse transcriptase inhibitor, commonly used as part of HIV treatment. All patients presented with bone pain, electrolyte and radiographic abnormalities which improved with discontinuation of tenofovir. Although, there have been several studies demonstrating causality between tenofovir and Fanconi syndrome, there are only six previously reported cases of patients developing osteomalacia and fractures since the introduction of tenofovir in 2001. In addition to asymptomatic osteopenia, hypophosphatemic osteomalacia is an important, reversible adverse effect of tenofovir.

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