Hypo-vitaminosis D in Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus and Ankylosing Spondylitis
|Mohamed Ismail Abdel Kareem1, Reem Hamdy A Mohammed2*, Hanan Sayed M Abozaid3, Mohamed Moneer Rayanv4, Abeer Mohamed Mohamed5 and Nihal Ahmad Fathi6|
|1Rheumatology and Rehabiltation, Al-Azhar Faculty of Medicine Assuit Egypt|
|2Rheumatology and Rehabilitation, Kasr Alaini School of Medicine Cairo University Hospital, Cairo Egypt|
|3Rheumatology and Rehabilitation, Faculty of Medicine, Sohag University, Egypt|
|4Rheuamtology and Physical Medicine, Al-Azhar faculty of medicine Assuit, Egypt|
|5Clinical Pathology, Faculty of medicine Sohag University, Egypt|
|6Rheumatology and Rehabiltation, Assuit University, Egypt|
|Corresponding Author :||Reem Hamdy A Mohammed
Rheumatology and Rehabilitation
Kasr Alaini School of Medicine Cairo
University Hospital, Cairo Egypt
E-mail: [email protected]
|Received: August 14, 2015 Accepted: October 28, 2015 Published: October 30, 2015|
|Citation: Kareem MIA, Mohammed RHA, Abozaid HSM, Rayan MM, Mohamed AM, et al. (2015) Hypo-vitaminosis D in Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus and Ankylosing Spondylitis. J Clin Cell Immunol 6:369. doi:10.4172/2155-9899.1000369|
|Copyright: © 2015 Kareem MIA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Hypo-vitaminosis D and its relevance to the stability of the immune system represent an interesting investigational topic in the field of rheumatology.
Objectives: survey hypo-vitaminosis D and its relation to disease activity parameters in a population of patients with autoimmune diseases.
Materials and methods: case control study including 70 patients: 30 patients with rheumatoid arthritis (RA), 30 patients with systemic lupus erythematosus (SLE) and 10 patients with ankylosing spondylitis (AS). In vitro quantitative determination of serum 25-hydroxyvitamin D3 using the electro-chemi-luminescence immunoassay "ECLIA" was done. Serum concentrations ≥ 30 ng/ml has been considered sufficient and levels between 11 ng/ml-29 ng/ml has been considered insufficient, whilst patients with levels ≤ 10 ng/ml has been considered deficient. Fifty healthy control subjects were included.
Results: Hypo-vitaminosis D was reported in 91.4% of the patients vs. 68% of the control group. The mean values of vitamin D in the population with AID was significantly lower than in controls (16.14 ± 9.32 ng/ml vs 24.61 ± 8.36 ng/ml, t=-5.05, P<0.01**, 95% CI=-12.31-5.31). The majority of patients (57.1%) had insufficiency vs 34.3% with vitamin D deficiency. Vitamin D levels inversely correlated with the ESR (r=-0.23, P=0.04) and with the SLEDAI score in SLE (r=-0.419, P=0.02). Regression analysis identified the presence of an autoimmune disease as a potentially significant risk factor for vitamin D deficiency (P<0.001).
Conclusion: The study reported a higher prevalence of hypo-vitaminosis D with autoimmune diseases. Lower levels of vitamin D correlated with higher ESR in all patients and with the SLEDAI score.