alexa Hypo-vitaminosis D in Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus and Ankylosing Spondylitis
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Research Article

Hypo-vitaminosis D in Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus and Ankylosing Spondylitis

Mohamed Ismail Abdel Kareem1, Reem Hamdy A Mohammed2*, Hanan Sayed M Abozaid3, Mohamed Moneer Rayanv4, Abeer Mohamed Mohamed5 and Nihal Ahmad Fathi6
1Rheumatology and Rehabiltation, Al-Azhar Faculty of Medicine Assuit Egypt
2Rheumatology and Rehabilitation, Kasr Alaini School of Medicine Cairo University Hospital, Cairo Egypt
3Rheumatology and Rehabilitation, Faculty of Medicine, Sohag University, Egypt
4Rheuamtology and Physical Medicine, Al-Azhar faculty of medicine Assuit, Egypt
5Clinical Pathology, Faculty of medicine Sohag University, Egypt
6Rheumatology and Rehabiltation, Assuit University, Egypt
Corresponding Author : Reem Hamdy A Mohammed
Rheumatology and Rehabilitation
Kasr Alaini School of Medicine Cairo
University Hospital, Cairo Egypt
Tel: +20-2-23641088
E-mail: [email protected]
Received: August 14, 2015 Accepted: October 28, 2015 Published: October 30, 2015
Citation: Kareem MIA, Mohammed RHA, Abozaid HSM, Rayan MM, Mohamed AM, et al. (2015) Hypo-vitaminosis D in Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus and Ankylosing Spondylitis. J Clin Cell Immunol 6:369. doi:10.4172/2155-9899.1000369
Copyright: © 2015 Kareem MIA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Hypo-vitaminosis D and its relevance to the stability of the immune system represent an interesting investigational topic in the field of rheumatology.

Objectives: survey hypo-vitaminosis D and its relation to disease activity parameters in a population of patients with autoimmune diseases.

Materials and methods: case control study including 70 patients: 30 patients with rheumatoid arthritis (RA), 30 patients with systemic lupus erythematosus (SLE) and 10 patients with ankylosing spondylitis (AS). In vitro quantitative determination of serum 25-hydroxyvitamin D3 using the electro-chemi-luminescence immunoassay "ECLIA" was done. Serum concentrations ≥ 30 ng/ml has been considered sufficient and levels between 11 ng/ml-29 ng/ml has been considered insufficient, whilst patients with levels ≤ 10 ng/ml has been considered deficient. Fifty healthy control subjects were included.

Results: Hypo-vitaminosis D was reported in 91.4% of the patients vs. 68% of the control group. The mean values of vitamin D in the population with AID was significantly lower than in controls (16.14 ± 9.32 ng/ml vs 24.61 ± 8.36 ng/ml, t=-5.05, P<0.01**, 95% CI=-12.31-5.31). The majority of patients (57.1%) had insufficiency vs 34.3% with vitamin D deficiency. Vitamin D levels inversely correlated with the ESR (r=-0.23, P=0.04) and with the SLEDAI score in SLE (r=-0.419, P=0.02). Regression analysis identified the presence of an autoimmune disease as a potentially significant risk factor for vitamin D deficiency (P<0.001).

Conclusion: The study reported a higher prevalence of hypo-vitaminosis D with autoimmune diseases. Lower levels of vitamin D correlated with higher ESR in all patients and with the SLEDAI score.

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