alexa Hypo-vitaminosis D in Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus and Ankylosing Spondylitis
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Hypo-vitaminosis D in Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus and Ankylosing Spondylitis

Mohamed Ismail Abdel Kareem1, Reem Hamdy A Mohammed2*, Hanan Sayed M Abozaid3, Mohamed Moneer Rayanv4, Abeer Mohamed Mohamed5 and Nihal Ahmad Fathi6
1Rheumatology and Rehabiltation, Al-Azhar Faculty of Medicine Assuit Egypt
2Rheumatology and Rehabilitation, Kasr Alaini School of Medicine Cairo University Hospital, Cairo Egypt
3Rheumatology and Rehabilitation, Faculty of Medicine, Sohag University, Egypt
4Rheuamtology and Physical Medicine, Al-Azhar faculty of medicine Assuit, Egypt
5Clinical Pathology, Faculty of medicine Sohag University, Egypt
6Rheumatology and Rehabiltation, Assuit University, Egypt
Corresponding Author : Reem Hamdy A Mohammed
Rheumatology and Rehabilitation
Kasr Alaini School of Medicine Cairo
University Hospital, Cairo Egypt
Tel: +20-2-23641088
E-mail: [email protected]
Received: August 14, 2015 Accepted: October 28, 2015 Published: October 30, 2015
Citation: Kareem MIA, Mohammed RHA, Abozaid HSM, Rayan MM, Mohamed AM, et al. (2015) Hypo-vitaminosis D in Patients with Rheumatoid Arthritis, Systemic Lupus Erythematosus and Ankylosing Spondylitis. J Clin Cell Immunol 6:369. doi:10.4172/2155-9899.1000369
Copyright: © 2015 Kareem MIA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at Pubmed, Scholar Google


Hypo-vitaminosis D and its relevance to the stability of the immune system represent an interesting investigational topic in the field of rheumatology.

Objectives: survey hypo-vitaminosis D and its relation to disease activity parameters in a population of patients with autoimmune diseases.

Materials and methods: case control study including 70 patients: 30 patients with rheumatoid arthritis (RA), 30 patients with systemic lupus erythematosus (SLE) and 10 patients with ankylosing spondylitis (AS). In vitro quantitative determination of serum 25-hydroxyvitamin D3 using the electro-chemi-luminescence immunoassay "ECLIA" was done. Serum concentrations ≥ 30 ng/ml has been considered sufficient and levels between 11 ng/ml-29 ng/ml has been considered insufficient, whilst patients with levels ≤ 10 ng/ml has been considered deficient. Fifty healthy control subjects were included.

Results: Hypo-vitaminosis D was reported in 91.4% of the patients vs. 68% of the control group. The mean values of vitamin D in the population with AID was significantly lower than in controls (16.14 ± 9.32 ng/ml vs 24.61 ± 8.36 ng/ml, t=-5.05, P<0.01**, 95% CI=-12.31-5.31). The majority of patients (57.1%) had insufficiency vs 34.3% with vitamin D deficiency. Vitamin D levels inversely correlated with the ESR (r=-0.23, P=0.04) and with the SLEDAI score in SLE (r=-0.419, P=0.02). Regression analysis identified the presence of an autoimmune disease as a potentially significant risk factor for vitamin D deficiency (P<0.001).

Conclusion: The study reported a higher prevalence of hypo-vitaminosis D with autoimmune diseases. Lower levels of vitamin D correlated with higher ESR in all patients and with the SLEDAI score.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]om

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version