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ISSN: 2380-2391

Journal of Environmental Analytical Chemistry
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Research Article

Identification, Mechanisms and Kinetics of Macrolide Degradation Product Formation under Controlled Environmental Conditions

Igal Gozlan1,2,3, Ilana Koren1,2 and Dror Avisar1,3*

1The Hydrochemistry Laboratory, Department of Geography and Environmental Studies, Tel Aviv University, Tel Aviv, Israel

2The Porter School of Environmental Studies, Tel Aviv University, Tel Aviv, Israel

3The Water Research Center, Tel Aviv University, Tel Aviv, Israel

*Corresponding Author:
Avisar D
The Water Research Center
Hydrochemistry Laboratory
Tel Aviv University
Tel Aviv 69978, Israel
Tel: 97236405534
E-mail: [email protected]

Received Date: December 29, 2015; Accepted Date: January 08, 2016; Published Date: January 25, 2016

Citation: Gozlan I, Koren I, Avisar D (2016) Identification, Mechanisms and Kinetics of Macrolide Degradation Product Formation under Controlled Environmental Conditions. J Environ Anal Chem 3:171. doi:10.4172/2380-2391.1000171

Copyright: © 2016 Gozlan I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Erythromycin, azithromycin, clarithromycin and roxithromycin are antibiotics belonging to the widely used macrolide group. Their presence in the environment has been much investigated, despite the rapid degradation of Erythromycin to its spiroketal degradation product. In this study, the formation of macrolide degradation products was investigated in various aqueous solutions, each containing 100 μg/mL of the respective macrolide, under controlled artificial conditions: three phosphate buffer solutions (pH 5, pH 7 and pH 8.5), and a buffer solution at pH 7 with the addition of humic acids. Two solutions from natural sources were also examined: secondary effluent and tap water. The obtained degradation products were identified by their HRMS and NMR spectra (for Erythromycin-spiroketal, obtained from pure compounds isolated by preparative HPLC) as: N-oxide, N-desmethyl and N-didesmethyl forms of all examined macrolides. These degradation products were obtained only under irradiation by sunlight, while the Erythromycin-H2O degradation products were also obtained in the shade. The secondary effluent was the most significant medium for achieving macrolide degradation products. According the degradation product’s t1/2 values obtained in the secondary effluent, the azithromycin was most rapidly degraded (23 hours). Furthermore, results suggested that the degradation process was activated by sunlight irradiation energy, and that the degradation mechanism started with the transfer of an electron from the amine group to O2 to produce the radical ions RMe2N·+ and O2 ·- as intermediates and production of the N-oxide and N-desmethyl macrolide degradation products. The kinetics of macrolide degradation was calculated as a first-order reaction.

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