Identification of a Point Mutation Causing Splitting of Antigenic Domain in M1 Protein of H5n1 Strain from 2006 Outbreak in India
Tamanna Anwar and Asad U Khan*
Interdisciplinary Biotechnology Unit Aligarh Muslim University, Aligarh 202002 India
- *Corresponding Author:
- Dr Asad U Khan
Lecturer, Interdisciplinary Biotechnology Unit
AMU,Aligarh 202002 India
Tel : 091-571-2723088,
Fax :091-571- 2721776,
E-mail : [email protected]
Received Date: August 01, 2008; Accepted Date: September 08, 2008; Published Date: September 13, 2008
Citation: Tamanna A, Asad UK (2008) Identification of a Point Mutation Causing Splitting of Antigenic Domain in M1 Protein of H5N1 Strain from 2006 Outbreak in India. J Proteomics Bioinform 1:302-306. doi:10.4172/jpb.1000038
Copyright: © 2008 Tamanna A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Influenza virus shows great variation in virulence. Numerous influenza virulence studies have sought to define the roles of each viral gene in disease production.To understand M1 protein it is necessary to study the functional properties of its distinct domains. Until now, in silico studies on M1 protein of Influenza A H5N1 virus are limited. The purpose of this study was to analyze the antigenic domains of the M1 protein of H5N1 strains found epidemic in Navapur (ABG88883) and Jalgaon, India (ABJ96491) during 2006 outbreak, and to identify antigenic differences between M1 proteins of other strains from different origin. It was noticed that the splitting of antigenic domain within position 48 to 69 of M1 was due to point mutation at position 59 from Isoleucine to Methionine. The antigenic regions identified here might be important for the development of diagnostic test for Influenza A H5N1 infection showing discrimination between different antigenic types of M1 protein of Influenza A H5N1.