alexa Identification of CYP3A5 and CYP2B6 Polymorphisms in Porphyria Cutanea Tarda Associated to Human Immunodeficiency Virus
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
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Case Report

Identification of CYP3A5 and CYP2B6 Polymorphisms in Porphyria Cutanea Tarda Associated to Human Immunodeficiency Virus

Jimena V. Lavandera1, Victoria E. Parera1, Maria Victoria Rossetti1,2, Alcira M. Del C. Batlle1* and Ana Maria Buzaleh1,2

1Centro de Investigaciones sobre Porfirinas y Porfirias (CIPYP), Hospital de Clínicas -CONICET, Argentina

2Department of Biological Chemistry, Facultad de Ciencias Exactas y Naturales, University of Buenos Aires, Argentina

*Corresponding Author:
Prof. Alcira Batlle
Viamonte 188l 10º “A”, C1056ABA - BUENOS AIRES, Argentina
Tel: 54 11 4812 3357
Fax: 54 11 4811 7447
E-mail: [email protected]

Received date: October 07, 2011; Accepted date: November 02, 2011; Published date: November 06, 2011

Citation:Lavandera JV, Parera VE, Rossetti MV, Del C. Batlle AM, Buzaleh AM (2011) Identification of CYP3A5 and CYP2B6 Polymorphisms in Porphyria Cutanea Tarda Associated to Human Immunodeficiency Virus. J Clin Exp Dermatol Res S2:006. doi:10.4172/2155-9554.S2-006

Copyright: ©2011 Lavandera JV, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract


To date, few or no data concerning the prevalence of polymorphisms in drug metabolism genes of antiretroviral drugs have been reported in the Argentinean population or in porphyric individuals worldwide. The purpose of the current investigation was to determine whether interindividual differences in cytochrome P450 3A5 (CYP3A) and 2B6 (CYP2B6) genes could influence the triggering of Porphyria Cutanea Tarda (PCT) in subjects with human immunodeficiency virus (HIV) after antiretroviral exposure.
A total of 141 subjects, 60 control volunteers and 81 unrelated individuals with PCT were included in the study. In the porphyric group, 21 individuals were HIV positive. To evaluate the presence of the alleles CYP3A5*3, CYP3A5*6 and CYP2B6*6 a polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) analysis was performed.
The frequencies of CYP3A5*3 were 0.91 in control group, 0.89 in PCT patients and 0.89 in PCT-HIV. CYP2B6*6 frequencies were 0.31 in control group, 0.34 in PCT group and 0.30 in PCT-HIV group. We have shown that the allelic frequencies of CYP3A5*3 or CYP2B6*6 in our population were similar to those reported for other Caucasian populations. Although, we have not found significant differences in polymorphisms of CYP3A5 and CYP2B6 between the different groups analyzed, there are an enormous number of biological variables that may influence antiretroviral treatment, like other genetic polymorphisms of phase I or phase II enzymes, or transporters like multidrug resistance transporter gene (MDR1), which can contribute to antiretroviral drug toxicities and response or even it is possible that the PCT-HIV association has more than one factor responsible for the onset of PCT symptoms.

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