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ISSN: 2157-7609

Journal of Drug Metabolism & Toxicology
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Research Article

Identification of MHC Class, Transports Antigenic Peptides from Naja melanoleuca Long Neurotoxin 1

Sherkhane AS1, Changbhale SS1 and Gomase VS2*

1The Global Open University, Nagaland, India

2Dr Babasaheb Ambedkar Marathwada University, Aurangabad, India

*Corresponding Author:
Virendra S Gomase
Dr Babasaheb Ambedkar Marathwada University, Aurangabad, India
Tel: +91-9987770696
E-mail: [email protected]

Received Date: May 30, 2014; Accepted Date: July 23, 2014; Published Date: July 30, 2014

Citation: Sherkhane AS, Changbhale SS, Gomase VS (2014) Identification of MHC Class, Transports Antigenic Peptides from Naja melanoleuca Long Neurotoxin 1. J Drug Metab Toxicol 5:169. doi: 10.4172/2157-7609.1000169

Copyright: © 2014 Sherkhane AS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Long neurotoxin 1 is a dangerous protein occurs in N. melanoleuca. It is highly dangerous snake due to the quantity of venom inject in a single bite. Peptide fragments of N. Melanoleuca Long neurotoxin 1 antigen protein having 71 amino acids, which shows 63 nanomers can be used to select nanomers for use in synthetic peptide vaccine design and to increase the understanding of roles of the immune system against snake bite. We use to apply computational intelligence algorithm PSSM (Position Specific Scoring Matrices) for the Prediction of MHC class-I binding peptides, we also predict antigenicity, Solvent accessibility, polar and nonpolar residue to analyses the membrane-spanning regions (hydrophobic) or regions that are likely exposed on the surface of proteins (hydrophilic domains) that are potentially antigenic that allows potential drug targets to identify active sites, for protection of host form Snake bites and to design synthetic peptide vaccine.

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