alexa Identification of Niclosamide as a New Lead Compound to Suppress the Metastasis of Prostate Cancer Cells | OMICS International | Abstract
ISSN: 2161-0444

Medicinal Chemistry
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Review Article

Identification of Niclosamide as a New Lead Compound to Suppress the Metastasis of Prostate Cancer Cells

Xiaomei Ren, Zhang Zhang, Lei Duan, and Ke Ding*

Institute of Chemical Biology, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, #190 Kaiyuan Avenue, Guangzhou Science Park, Guangzhou, China

*Corresponding Author:
Ke Ding
Institute of Chemical Biology
Guangzhou Institute of Biomedicine and Health
Chinese Academy of Sciences, #190 Kaiyuan Avenue
Guangzhou Science Park, Guangzhou, China
Tel: 86-20-32015276
E-mail: [email protected]

Received date: March 24, 2014; Accepted date: April 25, 2014; Published date: April 28, 2014

Citation: Ren X, Zhang Z, Duan L, Ding K (2014) Identification of Niclosamide as a New Lead Compound to Suppress the Metastasis of Prostate Cancer Cells. Med chem 4:511-516. doi: 10.4172/2161-0444.1000187

Copyright: © 2014 Ren X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Prostate cancer is one of the most common cancer types among males. Metastasis in advanced stages of prostate cancer makes the disease refractory to current treatments and is the leading cause of death of advanced prostate cancer. Drugs targeting metastasis may provide new therapeutic strategies for advanced prostate cancer. We identified the traditional antihelminthic drug niclosamide to have great potential in suppressing the metastatic process of prostate cancer. The drug potently inhibited the migration and invasion of the DU145 prostate cancer cell line. It significantly suppressed the protein levels of key members of the matrix metalloproteinase family (MMP2 and MMP9), as well as cadherins and catenins (E-/N-cadherin and β-catenin), all of which are critical factors in the metastastic process. Further investigation suggested that the motility inhibition of niclosamide on DU145 cells was highly correlated to its suppression of the STAT3 and MAPK signaling pathways.

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