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ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
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Review Article

Identifying Local Structural and Optical Derangement in the Neural Retina of Individuals with Type 1 Diabetes

Delia DeBuc1*, Erika Tatrai2, Lenke Laurik2, Boglarka Eniko Varga2, Veronika Olvedy2, Aniko Somogyi3, William E. Smiddy1 and Gabor Mark Somfai2
1Department of Ophthalmology, University of Miami, Miami, FL, USA
2Department of Ophthalmology, Semmelweis University, Budapest, Hungary
32nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
Corresponding Author : Delia Cabrera DeBuc
Bascom Palmer Eye Institute
University of Miami, Miller School of Medicine
1638 NW Tenth Avenue, Miami, FL 33136, USA
Tel: 305-482-4376
Fax: 305-326-6547
E-mail: [email protected]
Received June 03, 2013; Accepted August 02, 2013; Published August 08, 2013
Citation: DeBuc D, Tatrai E, Laurik L, Varga BE, Olvedy V, et al. (2013) Identifying Local Structural and Optical Derangement in the Neural Retina of Individuals with Type 1 Diabetes. J Clin Exp Ophthalmol 4:289. doi:10.4172/2155-9570.1000289
Copyright: © 2013 DeBuc D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Background: To identify local structural and optical derangement in the neural retina of individuals with type 1 diabetes having early diabetic retinopathy (DR) and compare with healthy non-diabetic controls and type 1 diabetic individuals having no DR.
Methods: Optical coherence tomography (TDOCT) examination was performed on a total of 74 healthy eyes, 38 eyes with type 1 diabetes mellitus (DM) with no retinopathy and 43 eyes with mild DR (MDR). A total of 6 intraretinal layers were segmented on OCT images. Thickness and reflectance-based measurements were extracted for each OCT scan using features measured locally for each intraretinal layer.
Results: In the analysis where local measures were averaged in the separated macular regions outside the foveola, the mean thickness values of the outer segment of photoreceptors (OS) in the perifoveal region, ganglion cell and inner plexiform layer (GCL+IPL) complex in the parafoveal and outer plexiform layer (OPL) in the foveal region were significantly smaller (13%, 8% and 36%; respectively, p<0.001) when comparing MDR eyes with controls. The mean thickness values of the OPL (foveal region, 27%, p<0.001) and the OS (parafoveal (24%) and perifoveal (23%), p<0.001) were significantly smaller when comparing MDR with DM eyes. The reflectance-based measures were significantly smaller for all layers in MDR eyes compared with healthy and DM eyes (7-36%, p<0.001).
Conclusions: Our results show OCT is capable of detecting selective layer thinning and that the optical properties extracted from OCT images add significant evidence to the morphological information directly provided by OCT. It also suggests that the outer segment of the photoreceptor layer may be vulnerable in both type 1 diabetic individuals with and without early DR. Our results might also indicate that an early sign of vascular alteration development could be detected by investigating the changes in optical properties and thickness of the OPL.

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