alexa Identifying Molecular Chaperones as Therapeutic Targets for Cancer: A Mini Review
ISSN: 2167-0501

Biochemistry & Pharmacology: Open Access
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Review Article

Identifying Molecular Chaperones as Therapeutic Targets for Cancer: A Mini Review

Ahmad A1*, Farwell MA1 and Muzaffar M2

1Department of Biology, East Carolina University, Greenville, NC 27858, USA

2Division of Hematology and Oncology, Brody School of medicine, ECU, Greenville, NC 27858, USA

*Corresponding Author:
Ahmad A
Department of Biology
East Carolina University
Greenville, NC 27858, USA
Tel: 252-737-4777
Fax: 252-328-4178
E-mail: [email protected]

Received Date: November 26, 2016; Accepted Date: February 03, 2017; Published Date: February 07, 2017

Citation: Ahmad A, Farwell MA, Muzaffar M (2017) Identifying Molecular Chaperones as Therapeutic Targets for Cancer: A Mini Review. Biochem Pharmacol (Los Angel) 6:224. doi: 10.4172/2167-0501.1000224

Copyright: © 2017 Ahmad A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Cancer is the name given to a complex set of diseases that follow a common pathway of progression i.e., localized proliferation, invasion and metastases. The disease is common world over and the number of affected people (14.9 million in 2013) is projected to increase further in coming decades. The treatment regimen at present is a combination of surgery, chemotherapy and/or radiation. Significant numbers of patients exhibit resistance to these modalities and experience relapses. The cost of treatment, emotional burden and effect on standard quality of life due to cancer is huge. Research over last few decades has broadened our understanding of cancer. At the molecular level detailed studies of many cancers have resulted in characterization of proteins for efficient and targeted therapeutic drug design. Molecular chaperones are such groups that have been targeted over last few decades for development of anticancer compounds. This review is aimed at compiling the information relevant to this field.

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