alexa Identifying Some Risk Factors of Time to Recurrent Relapses in Bipolar I Disorder Patients using Frailty Model of Survival Analysis
ISSN: 2378-5756

Journal of Psychiatry
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Identifying Some Risk Factors of Time to Recurrent Relapses in Bipolar I Disorder Patients using Frailty Model of Survival Analysis

Seyede Solmaz Taheri1, Mohammad Reza Khodaie Ardakani2, Masoud Karimlou1 and Mehdi Rahgozar1*

1Department of Biostatistics, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

2Department of Psychiatry, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.

*Corresponding Author:
Mehdi Rahgozar
Department of Biostatistics
University of Social Welfare and Rehabilitation Sciences
Tehran, Iran
Tel: +98-21-22180146
E-mail: [email protected]

Received Date: March 19, 2016; Accepted Date: June 28, 2016; Published Date: July 05, 2016

Citation: Taheri SS, Ardakani MRK, Karimlou M, Rahgozar M (2016) Identifying Some Risk Factors of Time to Recurrent Relapses in Bipolar I Disorder Patients using Frailty Model of Survival Analysis J Psychiatry 19:376. doi:10.4172/ jop.1000376

Copyright: © 2016 Taheri SS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: Bipolar I disorder patients often experience relapse once and even more with no limit on number of relapses. The time to relapses of these patients are rarely studied particularly considering heterogeneity across individuals. The aim of this study was to identify some risk factors of time to recurrent relapses in bipolar I disorder patients with a recurrent event model in survival analysis.
Methods: In a retrospective longitudinal study, data of medical records of 526 bipolar I disorder patients who had referred to Razi Psychiatric hospital in Tehran from 1993 to 2011 with at least one relapse, with-out relapse in other hospitals or home in this duration, were investigated and time to recurrent relapses were collected in months. Semiparametric penalized frailty model which consider whit-in subject correlation and heterogeneity across individuals, was applied to identify the risk factors of recurrent time to relapses.
Results: Significant frailty parameter (p<0.001) prove presence of heterogeneity among data. In frailty model the effects of substance abuse (p=0.041), regular fluctuation (p=0.002) and marital status (p=0.009) were significant on the hazard of recurrent times to relapses but other variables showed no significant effect.
Conclusions: Substance abuse, marital status and RF are important risk factors in order to plan for postpone the time to next relapses. More studies are required to clear out the effect of other covariates with this model.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version