Idiopathic Guttate Hypomelanosis: A Mini Review
Maria C Mazioti*
26 Perikleous Str, 18900, Salamina, Athens, Greece
- Corresponding Author:
- Maria C Mazioti
26 Perikleous Str, 18900, Salamina
Fax: +30 210 4658480
E-mail: [email protected]
Received date:: August 26, 2015; Accepted date:: September 09, 2015; Published date:: September 18, 2015
Citation: Mazioti MC (2015) Idiopathic Guttate Hypomelanosis: A Mini Review. Pigmentary Disorders 2:212. doi:10.4172/2376-0427.1000212
Copyright: © 2015 Mazioti MC. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Idiopathic guttate hypomelanosis is a common, acquired and benign dermatosis characterized by multiple, round or oval, hypopigmented to depigmented macules which mainly appear in upper and lower extremities. The major histopathologic findings are the reduced number of melanocytes in combination with structural (limited melanosomes and dendrites) or functional alterations (decreased tyrosinase activity). Although the underlying pathways are still being elucidated, genetic and environmental factors have been incriminated in its pathogenesis. Although accumulating number of studies supports the central role of sun exposure, a definite causal relationship cannot still be established. Despite the lack of symptoms idiopathic guttate hypomelanosis is a main aesthetic problem. Intense research has oriented towards the development of treatment modalities ranging from topical agents to invasive procedures. Until now the results are encouraging but they still need to be verified by future clinical and epidemiological studies.