IgA Nephropathy, Beta Thalassemia Minor, Psychosis and Deafness: A New Syndrome?
- *Corresponding Author:
- Sanda Mrabet
Department of Nephrology, Dialysis and Transplantation
Sahloul hospital, Sousse, Tunisia
Tel: +216 54 595 239
Fax: +216 73 367 451
E-mail: [email protected]
Received Date: May 14, 2015; Accepted Date: February 17, 2016; Published Date: February 24, 2016
Citation: Mrabet S, Bourkhis L, Abdelkarim SB, Azzabi A, Dorsaf Zellama et al. (2016) IgA Nephropathy, β Thalassemia Minor, Psychosis and Deafness: A New Syndrome?. J Nephrol Ther 6:237. doi:10.4172/2161-0959.1000237
Copyright: © 2016 Mrabet S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A 43-year-old male was admitted to our hospital because of renal failure and arterial hypertension. He was followed from the age of 15 years for psychosis and had no familial history of disease. Investigations revealed sensorineural deafness, a microcytic hypochromic anemia with normal ferritin leading to the diagnosis of β thalassemia minor and nephrotic syndrome. Examination of the renal biopsy specimen demonstrated severe Ig A nephropathy. No classic cause of IgA nephropathy was found. Review of literature showed two previous reported cases of Ig A nephropathy associated with β thalassemia minor but without deafness or psychosis. We wonder through this case if an explanation to this association may be made by a genetic defect.