alexa IgYs as an Alternative Approach to Antibiotics
ISSN: 2472-1212

Journal of Antimicrobial Agents
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Review Article

IgYs as an Alternative Approach to Antibiotics

Julia Zajac1, Andreas Schubert1 and Christopher Oelkrug1,2*

1Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Germany

2Fraunhofer Project Centre for Biomedical Engineering and Advanced Manufacturing, McMaster University, Hamilton, Canada

*Corresponding Author:
Christopher Oelkrug
Fraunhofer Institute for Cell Therapy and Immunology
Perlickstraße 1, 04103, Leipzig, Germany
49 1739726390;
E-mail: [email protected]

Received date: April 04, 2017; Accepted date: June 20, 2017; Published date: June 27, 2017

Citation: Zajac J, Schubert A, Oelkrug C (2017) IgYs as an Alternative Approach to Antibiotics. J Antimicrob Agents 3:144. doi: 10.4172/2472-1212.1000144

Copyright: © 2017 Zajac J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Misuse and overdose of antibiotics in agriculture and human disease lead to a worldwide problem of resistant bacteria. In 2012, 10,000 metric tons of antibiotics in the US and 8,000 in Europe were used in animals for the food industry. Resistance can be transferred within and between bacteria species, but also spread easily over to humans by contact with contaminated food, soil or infected animals and patients. To find a successful therapy against resistant microbes is extremely difficult due to the high cost of developing next generation antibiotics and its production, but also because of bacteria ability of developing new mechanisms against these drugs. Therefore, technology based on avian antibodies IgYs can be a strong alternative for antibiotic therapy. Advantages of IgYs include: low costs, effective and non-harmful method of production. But the strongest argument is that they cannot be affected by bacterial resistance. IgYs can be used not only as a preventative or therapeutic but also as growth promoters in food production. In this review we present the reasons for antibiotic resistance in bacteria and its consequences in the field of farming and human medicine, including molecular biology mechanisms and statistics. Furthermore we introduce IgYs as a promising and potential candidate for the replacement of antibiotics in the near future.


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