Imaging Mass Spectrometry and Its Methodological Application to Murine Tissue
- *Corresponding Author:
- Dr. Peter Hoffmann
Adelaide Proteomics Centre
Gate 8 Victoria Drive
Molecular Life Sciences Building Rm 1.49
University of Adelaide, Adelaide
South Australia 5005
Tel: (08) 8303 7521
Received Date: September 09, 2008; Accepted Date: November 02, 2008; Published Date: December 05, 2008
Citation: Gustafsson JOR, McColl SR, Hoffmann P (2008) Imaging Mass Spectrometry and Its Methodological Application to Murine Tissue. J Proteomics Bioinform 1: 458-463. doi: 10.4172/jpb.1000053
Copyright: © 2008 Gustafsson JOR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Imaging mass spectrometry (IMS) is an emerging technology, pioneered by Prof. Richard Caprioli’s group starting more than a decade ago. In this study we have demonstrated the simplicity of initial technological set up for IMS experiments with commercially available automated matrix deposition, MALDI-TOF mass spectrometry instrumentation and data handling software for image generation. We have applied two different concepts of automated matrix deposition on Murine brain sections and discussed their different features and capabilities in IMS.