Imaging Toxicity of Radiation Therapy in LiverHesheng Wang*
Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, 48109, USA
- *Corresponding Author:
- Hesheng Wang
Department of Radiation Oncology
University of Michigan, Ann Arbor
MI, 48109, USA
E-mail: [email protected]
Received date: June 28, 2012; Accepted date: June 29, 2012; Published date: June 30, 2012
Citation: Wang H (2012) Imaging Toxicity of Radiation Therapy in Liver. J Nucl Med Radiat Ther S6:e001. doi:10.4172/2155-9619.S6-e001
Copyright: © 2012 Wang H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Increasing radiation dose for better hepatic cancer control from radiation therapy (RT) is limited by the development of radiationinduced liver disease (RILD). Clinical syndrome of RILD occurs typically 2 weeks to 4 months after completion of RT. In severe cases, RILD can lead to liver failure and death. Using the Lyman-Kutcher- Burman NTCP model, the likelihood of developing RILD can be estimated based on the planned dose on the normal liver . However, the models solely based on dose distribution which ignores individual liver sensitivity to RT that may allow safe delivery of higher radiation dose on some patients. Imaging can quantitatively assess normal tissue response to RT, and thereby it may be able to characterize individual liver tolerance to radiation and provide surrogates to early predict the development of RILD.