Oral Health and Dental Management

Abstract

Imbalance of certain components of saliva in patients with fluorosis

Ludmila Gavriliuc, Elena Stepco, Pavel Godoroja, Vladimir Hornet

Fluorosis, caused by long-term intake of high levels of fluoride, is characterized by clinical manifestations
in bones and teeth. However, detrimental effects of high-fluoride intake are observed in
soft tissues also. Although fluorosis is irreversible, it could be prevented by appropriate and timely
intervention through understanding the process at biochemical and molecular levels. Increased production
of reactive oxygen species (ROS) and lipid peroxidation has been considered to play an
important role in the pathogenesis of chronic fluoride toxicity.
Saliva is a biological liquid of the human organism, and may be a reflection of the metabolic state.
The concentration of calcium (Ca2+), proline, hydroxyproline, creatinine and activity of alkaline
phosphatase were determined in the saliva of patients with fluorosis. An imbalance has been determined
in salivary components of patients with fluorosis. Correlation analysis among some biochemical
indexes in the patients with fluorosis indicated metabolic imbalance.