alexa Imino-4-Methoxyphenol Thiazole Derived Schiff Base Liga
ISSN: 2150-3494

Chemical Sciences Journal
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Research Article

Imino-4-Methoxyphenol Thiazole Derived Schiff Base Ligands: Synthesis, Spectral Characterization and Antimicrobial Activity

Vinusha HM1, Shiva Prasad K2*, Chandan S3 and Muneera Begum1

1Department of Chemistry, Sri Jayachamarajendra College of Engineering, Mysore, Karnataka, India

2Manipal Centre for Natural Sciences, Manipal University, Udupi, Karnataka, India

3Division of Biotechnology, Faculty of Life Sciences, JSS University, Mysore, Karnataka, India

Corresponding Author:
Shiva Prasad K
Manipal Centre for Natural Sciences
Manipal University, Udupi
Karnataka-576 104, India
Tel: +91-820-292 3571
Fax: +91-820-257 0062
E-mail: [email protected]

Received Date: August 04, 2015; Accepted Date: August 05, 2015; Published Date: August 12, 2015

Citation: Mariswamy VH, Shiva Prasad K, Shivamallu C, Begum M (2015) Imino-4-Methoxyphenol Thiazole Derived Schiff Base Ligands: Synthesis, Spectral Characterization and Antimicrobial Activity. Chem Sci J 6:102. doi:10.4172/2150-3494.1000102

Copyright: © 2015 Mariswamy VH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Two imino-4-methoxyphenol thiazole derived Schiff bases, 3-(5-nitrothiazol-2-ylimino)methyl)-4-methoxyphenol (4) and 3-(5-ethyl-1,3,4-thiadiazol-2-ylimino)methyl)-4-methoxyphenol (5) were synthesized by condensing 2-amino-5-nitrothiazole (1) and 2-amino-5-ethyl-1,3,4-thiadiazole (2) with 5-hydroxy-2-methoxybenzaldehyde (3). The obtained ligands were characterized by using UV-visible, 1H, 13C-NMR and MS techniques. Data obtained from the above techniques confirmed the molecular structures of the obtained compounds. The optimized structures of the compounds were done using ACD simulation software. The synthesized compounds were tested for their antibacterial (E. coli and R. solanacearum) and antifungal (F. oxysporum and A. niger) activities. The results from these studies showed that the compounds are moderately active against the tested species of bacteria and fungi. The microbial growth inhibition by compound 4 was significantly higher than compound 5. Microbial growth inhibition activity of both the compounds was less compared with their standard drugs.


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