Immune Abnormalities in Patients Meeting New Diagnostic Criteria for Chronic Fatigue Syndrome/Myalgic EncephalomyelitisBrenu EW1,2*, Johnston S1,2, Hardcastle SL1,2, Huth TK1,2, Fuller K1,2, Ramos SB1,2, Staines DR2,3 and Marshall-Gradisnik SM1,2
- *Corresponding Author:
- Ekua Weba Brenu
Griffith University, Griffith Health Centre
National Centre for Neuroimmunology and Emerging Diseases
Queensland, Australia 4222
Tel: +61 7 5678 0725
E-mail: [email protected]
Received date: October 24, 2013; Accepted date: November 12, 2013; Published date: November 14, 2013
Citation: Brenu EW, Johnston S, Hardcastle SL, Huth TK, Fuller K, et al. (2013) Immune Abnormalities in Patients Meeting New Diagnostic Criteria for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis. J Mol Biomark Diagn 4:152. doi:10.4172/2155-9929.1000152
Copyright: © 2013 Brenu EW, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Immunological abnormalities have been identified in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients fulfilling the 1994 Centers for Disease Control diagnostic criteria. Significant developments have been made to diagnostic criteria, but potential immunological markers have not been assessed in patients fulfilling these latest clinical requirements. Therefore, this study evaluated immunological parameters in patients that also fulfill the latest diagnostic criteria available known as the International Consensus Criteria.
Methods: The Immunological investigations including Natural Killer cell activity and phenotyping studies for dendritic cells, neutrophils, B cells and regulatory T cells were performed on whole blood samples collected from all participants using flow cytometric protocols. The physical functioning of all participants was also evaluated using scores from the Short Form Health Survey, and the World Health Organization Disability Adjustment Schedule. Results were compared according 1994 Centers of Disease Control and Prevention defined patients, and International Consensus Criteria defined patients, and healthy controls.
Results: Natural killer cell activity was consistently and significantly decreased, and regulatory T cells were significantly increased in both patient groups compared to healthy controls. Differences were found in human neutraphil antigens and expression of natural killer cell receptors between patient groups. Highly significant correlations were also found between physical status and some immune parameters in International Consensus Criteria defined patients.
Conclusion: This preliminary investigation on different diagnostic criteria suggests that the International Consensus Criteria may be more effective a detecting salient differences in the immune system.