alexa Immune Response Modulation by Tumor-Secreted Glycosphingolipids | OMICS International
ISSN: 2168-958X

Journal of Glycobiology
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Review Article

Immune Response Modulation by Tumor-Secreted Glycosphingolipids

Ricardo D Lardone, Ingrid Cely, Peter A Sieling, and Delphine J Lee*
Dirks/Dougherty Laboratory for Cancer Research, Department of Translational Immunology, John Wayne Cancer Institute at Providence Saint John’s Health Center, Santa Monica, CA 90404, USA
*Corresponding Author : Delphine J Lee
Dirks/Dougherty Laboratory for Cancer Research
Department of Translational Immunology
John Wayne Cancer Institute at Providence Saint John’s Health Center
Santa Monica, CA 90404, USA
Tel: 310-449-5265
Fax: 310-449-5273
E-mail: [email protected]
Received March 25, 2014; Accepted April 23, 2014; Published April 25, 2014
Citation: Lardone RD, Cely I, Sieling PA, Lee DJ (2014) Immune Response Modulation by Tumor-Secreted Glycosphingolipids. J Glycobiol 3:107. doi: 10.4172/2168-958X.1000107
Copyright: © 2014 Lardone RD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Although originally considered merely structural components of cellular membranes, glycosphingolipids (GSL) are now recognized as having critical effects on cellular physiology, including proliferation, differentiation, viral transformation and ontogenesis. In addition, a vast majority of human cancers have modified GSL composition compared to parental normal cells. These modifications may contribute to both tumor survival and exert striking effects on anti-tumor immunity. In this review, we discuss mechanisms of immune modulation by tumor-secreted GSL.

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