alexa Immune-based Therapy Clinical Trials in Hepatocellular Carcinoma | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

Immune-based Therapy Clinical Trials in Hepatocellular Carcinoma

Dai Liu1,2, Kevin F. Staveley-O’Carroll3-5* and Guangfu Li1,2*
1Department of Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
2Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 29425, USA
3Department of Surgery, University of Missouri, Columbia, MO 65212, USA
4Department of Molecular Microbiology and Immunology, University of Missouri, Columbia, MO 65212, USA
5sEllis Fischel Cancer Center, University of Missouri, Columbia, MO 65212, USA
Corresponding Authors : Guangfu Li
Hollings Cancer Center HO512F
86 Jonathan Lucas St, Department of Surgery
Medical University of South Carolina, Charleston, SC 29425
Tel: (843)-792-7576
Fax: (843)-876-3046
E-mail: [email protected]
  Kevin F Staveley-O’Carroll
One Hospital Driver, MC502, Department of Surgery
The University of Missouri, Columbia, MO 65212, USA
Tel: 573-882-8454
Fax: 573-884-6054
E-mail: [email protected]
Received: October 24, 2015 Accepted: December 01, 2015 Published: December 10, 2015
Citation: Liu D, Staveley-O’Carroll KF, Li G (2015) Immune-based Therapy Clinical Trials in Hepatocellular Carcinoma. J Clin Cell Immunol 6:376. doi:10.4172/2155-9899.1000376
Copyright: © 2015 Liu D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality and continues to increase. Current standard of care for patients with HCC only provides limited therapeutic benefit. Development of innovative strategies is urgently needed. Experience with immunotherapy in HCC is quite early, but rapidly rise in the recent 15 years. Multifaceted immune-based approaches have shown efficacy in achieving disease regression, representing the most promising new treatment approach. Here, we classify the ongoing or completed clinical trials in HCC in terms of the immune strategies to be used and assess their clinical outcomes. The generated information may be helpful in the design of future immune-based therapies for achieving ideal tumor control and maximizing anti-tumor immunity.

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