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Pre-Anesthetic Midazolam: A Randomized Trial with Three Different Routes of Administration | OMICS International | Abstract
ISSN: 2155-6148

Journal of Anesthesia & Clinical Research
Open Access

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Research Article

Pre-Anesthetic Midazolam: A Randomized Trial with Three Different Routes of Administration

Ashwani K. Chhibber1*, Kenneth Fickling2 and Stewart J. Lustik1

1Department of Anesthesiology, University of Rochester Medical Center, Rochester, NY

2Unity Health System, 1555 Long Pond Road, Rochester, NY

*Corresponding Author:
Ashwani K. Chhibber, MD
601 Elmwood Avenue, Dept. of Anesthesiology
Box 604, Rochester, NY 14642
Tel: 585-275-1386
Fax: 585-244-7271
E-mail: [email protected]

Received date: December 21, 2010; Accepted date: January 26, 2011; Published date: January 26, 2011

Citation: Chhibber AK, Fickling K, Lustik SJ (2011) Pre-Anesthetic Midazolam: A Randomized Trial with Three Different Routes of Administration. J Anesthe Clinic Res 2:118. doi: 10.4172/2155-6148.1000118

Copyright: © 2011 Chhibber AK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Aim: We aimed to determine the most effective route of midazolam administration in children prior to surgery to produce a cooperative patient.

Background: Pediatric patients often experience preoperative anxiety and uncooperativeness which has been associated with postoperative behavioral problems.

Methods/Materials: Ninety-nine children one to six years old with ASA status 1 or 2 requiring minor outpatient surgical procedures were enrolled in the study. Patients were randomized to receive preoperative midazolam rectally, nasally, or orally. Patients were graded on a three point cooperativeness scale at baseline, during midazolam administration, 20 minutes after administration, at parent separation, and at induction.

Results: Children receiving midazolam by the rectal route were more cooperative than the nasal or oral groups during administration of midazolam, at separation and at induction. The rectal group had similar cooperativeness to baseline at administration, while the nasal and oral groups were less cooperative at administration than at baseline.

Conclusions: In children undergoing surgical procedures under general anesthesia, rectal administration of midazolam, compared to oral or nasal routes, is better tolerated and more effective at alleviating perioperative uncooperativeness.

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