Immunoinformatics: Implications on Reverse Vaccinology
Mawadda Abd_Elraheem Awad _Elkareem and Mohammed Ahmed Salih*
School of Pharmacy, Biotechnology, Ahfad University for Women, Omdurman, Khartoum, Sudan
- *Corresponding Author:
- Mawadda Abdulraheem Elneel
School of Pharmacy, Biotechnology
Ahfad University for Women, Arda Street
Omdurman, Khartoum, Sudan
E-mail: [email protected]
Received Date: June 15, 2017; Accepted Date: June 20, 2017; Published Date: June 23, 2017
Citation: Elneel MA (2017) Immunoinformatics: Implications on Reverse Vaccinology. Immunochem Immunopathol 3:127. doi: 10.4172/2469-9756.1000127
Copyright: © 2017 Elneel MA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
One area in which immunological studies have had most immediate and successful application is in the field of vaccination. Vaccines represent one of the greatest interventions in modern medicine . Ever since Edward Jenner’s first use of a vaccine against smallpox in 1796, the use of vaccines has become indispensable to the eradication of disease . Then, Scientific progress has driven vaccine development from live attenuated and inactivated vaccines to purified recombinant one. The recent advances in bioinformatics, proteomics, immunoinformatics, structural biology and others have led to vaccinomics and reverse vaccinology as novel approaches for a generation of new vaccines . Reverse vaccinology relies on the genomic information to identify relevant protein antigens and the design of algorithm for mapping potential B and T cell epitopes for diagnostic or vaccine purposes .