Immunologic Abnormalities in β-Thalassemia
Ch D Asadov*
Institute of Hematology and Transfusiology, Baku, Azerbaijan
- *Corresponding Author:
- Ch D Asadov
Institute of Hematology and Transfusiology
E-mail: [email protected]
Received date: March 17, 2014; Accepted date: June 24, 2014; Published date: July 02 , 2014
Citation: Asadov ChD (2014) Immunologic Abnormalities in ß-Thalassemia. J Blood Disord Transfus 5:224. doi:10.4172/2155-9864.1000224
Copyright: © 2014 Asadov ChD. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Infectious complications are the important part of the clinical spectrum of thalassemia, being one of the main reasons of mortality rate in this disease. Data about the increased susceptibility to infections in thalassemia aroused interest in the study of the immune status in this disease. As a result of the researches considerable infringements of specific (all stages of phagocytosis), nonspecific immunity (the maintenance and functional activity of lymphocyte subsets) and humoral immunity (an increase of the immunoglobulins and a decrease of the activity of complement components) have been revealed. Immunological abnormalities in thalassemia are caused by either the illness, or therapy methods. The basis of the pathogenesis of the immunodeficiency in thalassemia is iron overload and allogenic stimulation caused by multiple blood transfusions. There are not numerous data about efficiency of the immunocorrection therapies for thalassmia patients.